Anticancer (in vitro) and Antiallergy Effects of Rice Bran Extracts

쌀겨 추출물의 항암효과(in vitro) 및 항알레르기 효과

  • Choi, Hyun-Im (Dept. of Occupational therapy, Sungduk college) ;
  • Ye, Eun-Ju (Efficacy and Safety Research Center for Traditional Oriental Medicine, Daegu Hanny University, Kyongbuk Technopark) ;
  • Kim, Soo-Jung (Efficacy and Safety Research Center for Traditional Oriental Medicine, Daegu Hanny University, Kyongbuk Technopark) ;
  • Bae, Man-Jong (Dept. of Herbal foodceutical Science, Daegu Haany University) ;
  • Yee, Sung-Tae (Dept. of Biology, Sunchon National University) ;
  • Park, Eun-Jung (Dept. of Biology, Sunchon National University) ;
  • Park, Eun-Mi (Efficacy and Safety Research Center for Traditional Oriental Medicine, Daegu Hanny University, Kyongbuk Technopark)
  • 최현임 (성덕대학 작업치료과) ;
  • 예은주 ((재)경북테크노파크 대구한의대학교 한방생명자원특화센터 효능검증원) ;
  • 김수정 ((재)경북테크노파크 대구한의대학교 한방생명자원특화센터 효능검증원) ;
  • 배만종 (대구한의대학교 한방식품약리학과) ;
  • 이성태 (순천대학교 생물학과) ;
  • 박정은 (순천대학교 생물학과) ;
  • 박은미 ((재)경북테크노파크 대구한의대학교 한방생명자원특화센터 효능검증원)
  • Published : 2006.12.29


This study was conducted to investigate the anticancer (in vitro) and antiallergy effects of rice bran extracts. In an anticancer test using Hep3B cells and HeLa cells, water and 60% ethanol extracts of rice bran inhibited the growth of Hep3B and HeLa cell lines and morphological changes were also observed. In Hep3B cell lines, water extract of rice bran showed a higer antiproliferating effect than 60% ethanol extract. The growth-inhibitory effect against HeLa cells were 30.9% for $1,000{\mu}g/mL$, 88.8% for $3,000{\mu}g/mL$ rice bran water extract. The expressions of $Fc{\varepsilon}RI$ mRNA and c-kit in HMC-1 (human mast cell) were decreased by 60% ethanol treatment but tryptase mRNA was not changed. The extracts of rice bran inhibited histamine release from RPMC (rat peritoneal mast cell) activated by compound 48/80. Rice bran water extract showed inhibitory effect of 87% at $0.01{\mu}g/mL$ concentration and 60% ethanol extract inhibited the release of histamine by 86% at $100{\mu}g/mL$ concentration.


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