Journal of Food Hygiene and Safety (한국식품위생안전성학회지)

The Korean Society of Food Hygiene and Safety (한국식품위생안전성학회)
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Assessment of Pubertal Development to Parabens-induced Estrogenic Effect in Male Mice

파라벤류가 수컷 성 성숙에 미치는 시험연구

  • Kim, Sun-Jung (Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University) ;
  • Hwang, Jae-Woong (Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University) ;
  • Park, Jung-Ran (Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University) ;
  • Lee, Seong-Hun (Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University) ;
  • Lee, Yeong-Geon (Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University) ;
  • Chung, Ji-Hye (Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University) ;
  • Jeong, Yun-Hyeok (Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University) ;
  • Lee, Soo-Jin (Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University) ;
  • Jung, Ji-Won (Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University) ;
  • Jung, Ji-Youn (Department of Companion and Laboratory Animal Science, Kongju National University) ;
  • Lee, Yong-Soon (Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University) ;
  • Kang, Kyung-Sun (Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University)
  • 김선중 (서울대학교 수의과대학 공중보건학교실) ;
  • 황재웅 (서울대학교 수의과대학 공중보건학교실) ;
  • 박정란 (서울대학교 수의과대학 공중보건학교실) ;
  • 이성훈 (서울대학교 수의과대학 공중보건학교실) ;
  • 이영건 (서울대학교 수의과대학 공중보건학교실) ;
  • 정지혜 (서울대학교 수의과대학 공중보건학교실) ;
  • 정윤혁 (서울대학교 수의과대학 공중보건학교실) ;
  • 이수진 (서울대학교 수의과대학 공중보건학교실) ;
  • 정지원 (서울대학교 수의과대학 공중보건학교실) ;
  • 정지윤 (공주대학교 산업과학대학 특수동물학과) ;
  • 이영순 (서울대학교 수의과 대학 공중보건학 교실) ;
  • 강경선 (서울대학교 수의과대학 공중보건학교실)
  • Published : 2006.12.30
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Abstract

Parabens are most wildly used in food, cosmetics and pharmaceutic products as preservatives caused of safety and cheap. we had examined that paraben had estrogenic activity through the in vivo and in vitro experiments in last year. We demonstrated that most of parabens(ethyl, butyl, propyl, isobutyl, isopropyl) increased significantly uterus weight as well as induced proliferation of MCF-7 cell and binding of estrogen receptor as endocrine disrupter compounds. In this study, we evaluated that whether parabens have effect on male reproductive system or not. the male rats were administrated parabens by oral injection then examined separation of preputial day for $PND23\simPND52$. As the results, most parabens delayed pubertal development compare to control group. The separation of preputial day of Butyl and Propyl parabens at high concentration were PND 44 days and PND 45days compared to control group as PND 40 days. Even though, parabens as endocrine disrupter wildly spread in food, cosmetics and pharmaceutic products, we didn't have the safe guideline. In abroad, they are re-evaluating safety assessment for parabens. In conclusion, parabens delayed pubertal development in juvenile parabens are consider as endocrine disrupter chemicals.

Keywords

References

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