Invasive Pulmonary Aspergillosis in a Whooper Swan (Cygnus c. cygnus)

큰고니에서 발생한 침습성 폐 아스퍼질러스 감염증 1례

  • Kim, Kyoo-Tae (Wild Animal Hospital, Daejeon Zoo Land) ;
  • Cho, Sung-Whan (College of Veterinary Medicine, Chungnam National University) ;
  • Son, Hwa-Young (College of Veterinary Medicine, Chungnam National University) ;
  • Ryu, Si-Yun (College of Veterinary Medicine, Chungnam National University)
  • 김규태 (대전동물원 동물병원) ;
  • 조성환 (충남대학교 수의과대학) ;
  • 손화영 (충남대학교 수의과대학) ;
  • 류시윤 (충남대학교 수의과대학)
  • Published : 2006.12.30

Abstract

Aspegillosis in free-living birds can be occurred mostly under poor weather and climate. But, captive birds tend to be more susceptible to infection and diagnosis was made usually at post mortem. A two months old Whooper swan(Cygnus c. cygmus) dying suddenly was found in a zoo without prior clinical signs. At necropsy, numerous well- demarcated yellow to white firm nodules were scattered throughout the air sacs and the lungs. Microscopically, granuloma formations were observed in the lung and air sacs. The margin of granuloma was surrounded by connective tissue barrier and was infiltrated with lymphocytes, and also observed giant cell near the granuloma. By Periodic acid Schiff reaction, hyphae were detected in granuloma of lung and air sacs. This case was diagnosed as an invasive pulmonary aspergillosis caused by Aspergillus fumigatus infection in a Whooper swan at a zoo.

Keywords

References

  1. Astorga RJ, Cubero MJ, Leon L. Serological survey of infections in waterfowl in the Guadalquivir marshes. Avian Dis 1994; 38: 371-375 https://doi.org/10.2307/1591966
  2. Chute HL, Richard JL. Fungal infections. In: Disease of Poultry, 10th ed. Iowa: Mosby-Wolfe. 1997: 351-360
  3. Dykstra MJ, Loomis M, Reininger K, Zombeck D, Faucette T. A comparison of sampling methods for airborne fungal spores during an outbreak of aspergillosis in the forest aviary of the north carolina zoological park. J Zoo Wildl Med 1997; 28: 454-463
  4. Ferrer C, Colom F, Frases S, Mulet E, Abad JL, Alio JL. Detection and identification of fungal pathogens by PCR and by ITS2 and 5.8S ribosomal DNA typing in ocular infections. J Clin Microbiol 2001; 39: 311-320
  5. Graczyk TK, Cranfield MR, Klein PN. Value of antigen and antibody detection and blood evaluation parameters in diagnosis of avian invasive aspergillosis. Mycopathologia 1997; 140: 121-127 https://doi.org/10.1023/A:1006805816537
  6. Graczyk TK, Cranfield MR. Maternal transfer of anti-Aspergillus spp. immunoglobulins in African black footed penguins. J Wildl Dis 1995; 31: 545-549 https://doi.org/10.7589/0090-3558-31.4.545
  7. Johnes, TC, Hunt RD. Aspergillosis. In: Veterinary Pathology, 5th ed. Philadelphia: Lea & Febiger. 1983: 667-669
  8. Julian RJ, Goryo M. Pulmonary aspergillosis causing right ventricular failure and ascites in meat type chickens. Avian Pathol 1990; 19: 643-654 https://doi.org/10.1080/03079459008418720
  9. Karesh WB, Uhart MM, Frere E, Gandini P, Braselton WE, Puche H, Cook RA. Health evaluation of free-ranging rockhopper penguins in Argentina. J Zoo Wildl Med 1999; 30: 25-31
  10. Kim SH, Hwang CY, Yoon JH, Youn HY, Yoshioka N, Kano R, Hasegawa A. Aspergillus niger pulmonary infection in a dog. Jp J Vet Med Sci 2003; 65: 1139-1140 https://doi.org/10.1292/jvms.65.1139
  11. Lass-Flori C, Speth C, Mayr A, Wurzner R, Dierich MP, Ulmer H. Diagnosing and monitoring of invasive aspergillosis during antifungal therapy by polymerase chain reaction: an experimental study in mice. Diagn Microbiol Infect Dis 2003; 8: 189-200
  12. Matsuda K, Seol MS, Kim YJ, Valieryevna VI, Lee HJ, Lim CW. Chroinc Aspergillus fumigatus infection in a Ostrich (Struthio camelus). J Vet Clin Med 2002; 19: 107-109
  13. McClenny N. Laboratory detection and identification of Aspergillus species by microscopic observation and culture: the traditional approach. Med Mycol 2005; 47: 569-572
  14. Tunev SS, Ehrhart EJ, Jensen HE, Foremen JH, Richter RA, Messick JB. Necrotizing mycotic vasculitis with cerebral infarction caused by Aspergillus niger in a horse with acute typhlocolitis. Vet Pathol 1999; 36: 347-351 https://doi.org/10.1354/vp.36-4-347
  15. Yu VL; Muder PR, Poorsatter A. Signification of isolation of Aspergillus from the respiration tract in diagnosis of invasive pulmonary aspergillosis. Am J Med 1986; 81: 249-254 https://doi.org/10.1016/0002-9343(86)90259-7
  16. 권효정,박미선,김대용,황철용,신남식. 아마존앵무에서 Aspergillus 감염증. 한국임상수의학회지 2004; 21: 413-415
  17. 김규태,조성환,손화영,류시윤. 자카스펭귄에서 발생한 Aspergillus fumigatus 감염증. 대한수의학회지 2004; 44: 615-619
  18. 김성권,김승곤,김신무. 임상진균학 서울: 고려의학. 1993: 225-227
  19. 남기홍. 사료중의 곰팡이와 곰팡이 독소에 대한 문제점과 가능한 대책. 한국가금학회지 1994; 21: 113-117
  20. 박미라,신종희,송정원,박영규,조덕,기승정,신명근,서순팔,양동욱. Spectrophotometric Broth Microdilution 법을 이용한 Aspergillus species의 항진균제 감수성 검사. 대한진단검사의학회지 2004; 24: 301-307
  21. 박윤희,김창기,이혁민,노경호,정준원,용동은,이경원. 다발성 골수종 환자에서 발생한 아스페르길루스에 의한 내인성 안구내염. 대한진단검사의학회지 2006; 26: 36-38 https://doi.org/10.3343/kjlm.2006.26.1.36
  22. 육현수,한규삼,이성재,임채웅,도홍기,임병무. Aspergillus sp 감염에 의한 닭 복강장막의 육아종성 결절 발생례. 한국가축위생학회지 1998; 21: 407-411
  23. 조경오,박남용,강문일,이근우. 타조에서 발생한 아스퍼질러스증. 한국임상수의학회지 2001; 18: 174-177
  24. 조남선,이진경,정미은,이동순,이승훈,홍석일. Aspergillus niger에 의한 급성 침습성 폐렴 1예. 대한임상병리학회지 1995; 15: 112-120