Korean Journal of Microbiology (미생물학회지)

The Microbiological Society of Korea (한국미생물학회)
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Biochemical Characteristics of Lrp (Leucine-responsive Regulatory Protein) as a Global Regulator in Escherichia coli

대장균의 Global 조절 단백질인 Lrp (Leucine-responsive Regulatory Protein)의 생화학적 특성

  • Lee, Chan-Yong (Department of Biochemistry, Chungnam National University) ;
  • Kim, So-Young (Department of Biochemistry, Chungnam National University) ;
  • Kim, Ryu-Ryun (Department of Biochemistry, Chungnam National University)
  • 이찬용 (충남대학교 자연과학대학 생화학과) ;
  • 김소영 (충남대학교 자연과학대학 생화학과) ;
  • 김류련 (충남대학교 자연과학대학 생화학과)
  • Published : 2006.12.30
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Abstract

Leucine-responsive Regulatory Protein (Lrp) is a global regulator involved in modulating a variety of metabolic functions, including the catabolism and anabolism of amino acids as well as pili synthesis. In addition, there is growing evidences that Lrp may play an important role when cells make transition between rich and lean nutritional conditions. In this review, the biochemical characteristics of Lrp are described to provide a good example that shows how bacteria adapt to nutrient limitation and environmental stress.

Leucine-responsive Regulatory Protein (Lrp)는 global 조절 단백질로서 아미노산의 합성 및 분해 작용과 pilin 생합성을 포함하는 다양한 대사기능을 조절하는데 관여한다. 또한 Lrp가 대장균의 성장 정지기의 유전자 발현에 매우 중요한 역할을 하는 것으로 최근의 여러 실험 결과에서 밝혀지고 있다. 따라서 본 총설에서는 세균들이 영양부족 등의 환경적인 스트레스상황을 어떻게 인지하고 유전자 발현 조절에 그 정보를 반영해 나가는지를 제시해 주는 종은 모텔 시스템으로서 Lrp의 생화학적 특성을 기술하였다.

Keywords

References

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