Microbiology and Biotechnology Letters (한국미생물·생명공학회지)

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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3',5'-Cyclic Adenosine Monophosphate (cAMP) as a Signal and a Regulatory Compound in Bacterial Cells

원핵세포에서 신호물질 및 조절인자로서의 3',5'-Cyclic Adenosine Monophosphate의 역할

  • Chun, Se-Jin (Department of Environment Science, Hankuk University of Foreign Studies) ;
  • Seok, Young-Jae (Laboratory of Macromolecular Interactions, School of Biological Science, Seoul National University) ;
  • Lee, Kyu-Ho (Department of Environment Science, Hankuk University of Foreign Studies)
  • 천세진 (한국외국어대학교 자연과학대학 환경학과) ;
  • 석영재 (서울대학교 자연과학대학 생명과학부) ;
  • 이규호 (한국외국어대학교 자연과학대학 환경학과)
  • Published : 2006.12.28
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Abstract

3',5'-cyclic adenosine monophosphate (cAMP) is an important molecule, which mediates diverse cellular processes. For example, it is involved in regulation of sugar uptake/catabolism, DNA replication, cell division, and motility in various acterial species. In addition, cAMP is one of the critical regulators for syntheses of virulence factors in many pathogenic bacteria. It is believed that cAMP acts as a signal for environmental changes as well as a regulatory factor for gene expressions. Therefore, intracellular concentration of cAMP is finely modulated by according to its rates of synthesis (by adenylate cyclase), excretion, and degradation (by cAMP phosphodiesterase). In the present review, we discuss the bacterial physiological characteristics governed by CAMP and the molecular mechanisms for gene regulation by cAMP. Furthermore, the effect of cAMP on phosphotransferase system is addressed.

Keywords

References

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