Korean Journal of Acupuncture

Society for Meridian and Acupoint (경락경혈학회)
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Acupuncture at Liver Meridian Protects the Dopaminergic Neuronal Damage in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's Disease Mouse Model

간경보사(肝經補瀉)가 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine로 유도된 파킨슨병 동물 모델에 미치는 영향

  • Kim Seung-Tae (Dept. of Meridian and Acupuncture, College of Korean Medicine, Kyunghee University) ;
  • Chae Youn-Byong (Dept. of Meridian and Acupuncture, College of Korean Medicine, Kyunghee University) ;
  • Kim Yun-Jung (College of Nursign Science, College of Medicine, Kyunghee University) ;
  • Kang Min-Jung (Dept. of Meridian and Acupuncture, College of Korean Medicine, Kyunghee University) ;
  • Jung Mi-Young (Dept. of Pharmacology, College of Medicine, Kyunghee University) ;
  • Chung Joo-Ho (Dept. of Pharmacology, College of Medicine, Kyunghee University) ;
  • Hahm Dae-Hyun (Acupuncture & Meridian Science Research Center(AMSRC), Kyunghee University) ;
  • Lee Sang-Jae (Institute of Korea Medicine for Healthy Living) ;
  • Lee Hye-Jung (Dept. of Meridian and Acupuncture, College of Korean Medicine, Kyunghee University) ;
  • Park Hi-Joon (Dept. of Meridian and Acupuncture, College of Korean Medicine, Kyunghee University)
  • 김승태 (경희대학교 한의과대학 경혈학교실) ;
  • 채윤병 (경희대학교 한의과대학 경혈학교실) ;
  • 김연정 (경희대학교 간호과학대학) ;
  • 강민정 (경희대학교 한의과대학 경혈학교실) ;
  • 정미영 (경희대학교 의과대학 약리학교실) ;
  • 정주호 (경희대학교 의과대학 약리학교실) ;
  • 함대현 (경희대학교 의과대학 침구경락과학연구센터) ;
  • 이상재 (한방유연구소) ;
  • 이헤정 (경희대학교 한의과대학 경혈학교실) ;
  • 박히준 (경희대학교 한의과대학 경혈학교실)
  • Published : 2006.12.27
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Abstract

Objectives : This study was designed to compare the effects of tonification and sedation methods of Liver Meridian in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease mice model. Methods : We injected MPTP (30 mg/kg, i.p.) or saline for 5 consecutive days. Acupuncture treatments were given to the mice with MPTP at LR8 and LR4 to tonify Liver Meridian (Liver+) or LR4 and LR2 to sedate it (Liver-) for 12 day. At the 12th day after first injection, mice were perfused, and then tyrosine hydroxylase (TH)-immunohistochemistry was performed in substantia nigra (SN) of their brains. After counting the number of TH-positive neurons, we compared their numbers among experimental groups. Results : The number of TH-positive neurons of Liver+ group was significantly increased compared to that of MPTP group in the SN. That of Liver-group was also increased more than MPTP group, but not significantly. Conclusions : Tonifying Liver Meridian might be effective therapeutic tools for the neuroprotection in subchronic MPTP-induced mice model.

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