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Effect of a Pholiota adiposa Extract on Fat Mass in Hyperlipidemic Mice

  • Cho, Soo-Muk (Rural Resources Development Institute, National Institute of Agricultural Science and Technology) ;
  • Lee, Young-Min (Rural Resources Development Institute, National Institute of Agricultural Science and Technology) ;
  • Lee, Dae-Hyoung (Department of Life Science and Genetic Engineering, Paichai University) ;
  • Chun, Hye-Kyung (Rural Resources Development Institute, National Institute of Agricultural Science and Technology) ;
  • Lee, Jong-Soo (Department of Life Science and Genetic Engineering, Paichai University)
  • Published : 2006.12.31

Abstract

The purpose of this study was to investigate the effect of a Pholiota adiposa extract on fat mass in hyperlipidemic mice fed on a high-fat diet. The water extracts from P. adiposa (ASI 24018) were not affected in the total triglyceride contents and epididymal fat mass in mice fed on a high-fat diet, but the retroperitoneal fat mass decreased significantly. This result suggests that the P. adiposa extract may be a potential candidate for use as a functional food that can act as a prophylactic against hyperlipidemia. However, the P. adiposa extract showed no effect in the total triglyceride contents and epididymal fat mass.

References

  1. Biggs, H. G., Erikson, T. A. and Moorehead, W. R. 1975. A manual colorimetric assay of triglyceride in serum. Clin. Chem. 21: 437-441
  2. Bischoff, K. M. and Rodwell, V. W. 1992. Biosynthesis and isolation of (S) and (R)-3-hydroxy-3-methylglutaryl coenzyme A. Biochem. Med. Metab. Biol. 48: 149-158 https://doi.org/10.1016/0885-4505(92)90060-C
  3. Daniel, A. B., Lydia, T., Stauffacher, C. V. and Rodwell, V. W. 1999a. Investigation of the conserved lysines of Syrian hamster 3-hydroxy-3-methylglutaryl coenzme A reductase. Biochem. 38: 15848-15852 https://doi.org/10.1021/bi9914311
  4. Daniel, A. B., Lydia, T., Stauffacher, C. V. and Rodwell, V. W. 1999b. Aminoethylcysteine can replace the active site lysine of Pseudomonas mevalonii 3-hydroxy-3-methylglutaryl coenzyme A reductase. Biochem. 38: 8879-8883 https://doi.org/10.1021/bi9902687
  5. Duncan, D. B. 1957. Multiple range test for correlated and heteroscedastic means. Biometrics 13: 164-176 https://doi.org/10.2307/2527799
  6. Folch, J., Less, M. and Sioanestanley, G. H. 1957. A simple method for the isolation and purification of total lipid from ani-mal tissues, J Biol Chem. 226: 497-597
  7. Frimpong, K., Darnay, B. G. and Rodwell, V. W. 1993. Syrian hamster 3-hydroxy-3-methylglutaryl coenzyme A reductase expressed in Escherichia coli: Production of homogeneous protein. Protein Expression Purification 4: 337-344 https://doi.org/10.1006/prep.1993.1044
  8. Frimpong, K. and Rodwell, V. W. 1994a. Catalysis by Syrian hamster 3-hydroxy-3-methylglutaryl-CoA reductase. Proposed roles of histidine 865, glutamate 558, and aspartate 766. J. Biol. Chem. 269: 11478-11483
  9. Frimpong, K. and Rodwell, V. W. 1994b. The active site of hamster 3-hydroxy-3-methylglutaryl-CoA reductase resides at the subunit interface and incorporates catalytically essential acidic residues from separate polypeptides. J. Biol. Chem. 269: 1217-1221
  10. Hargis P. S. 1988. Modifying egg yolk cholesterol in the domestic fowl-a review. World's Poultry Sci. J. 44: 17-29 https://doi.org/10.1079/WPS19880002
  11. Jeon, B. S., Park, J. W., Shin, G G., Kim, B. K., Kim, H. K., Cho, Y. S. and Cho, J. Y. 2004. Effect of fermented mushroom milk on hyperlipidemia and hepatic injury in streptozotocin-induced diabetic and zucker diabetic fatty rats. Food Sci. Biotechnol. 13: 567-580
  12. Koo, K. C., Lee, D. H., Kim, J. H., Yu, H. E., Park, J. S. and Lee, J. S. 2006. Production and characterization of antihypertensive angiotensin I-Converting enzyme inhibitor from Pholiota adiposa. J. Microbial. Biotechnol. 16: 757-763
  13. Kim, H. J., Lee, D. H., Hwang, Y. Y., Lee, K. S. and Lee, J. S. 2005. Characterization of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor from Pueraria thunbergiana. J Agric. Food Chem. 53: 5882-5888 https://doi.org/10.1021/jf0505978
  14. Lee, S. H., Park, H. J., Chun, H. K., Rhie, S. G. and Lee, Y. S. 2003. Supplementary effect of the rice germ oil on lipid metabolism in diabetic KK mice, Korean J Community Living Science 14: 59-65
  15. Oh, S. W., Lee, C. U. and Koh, J. B. 2004. Effects of Agaricus blazei murill on lipid metabolism in eats fed high fat diet. J Korean Soc Food Sci Nutr. 33: 821-826 https://doi.org/10.3746/jkfn.2004.33.5.821
  16. Yu, H. E., Cho, S. M., Seo, G. S., Lee, B. S., Lee, D. H. and Lee, J. S. 2006. Screening of bioactive compounds from mushroom Pholiota sp. Korea J. Mycol. 34: 15-21 https://doi.org/10.4489/KJM.2006.34.1.015
  17. Ziatkis, A., Zak, B. and Boyle, A. J. 1953. A new method for the direct determination of serum cholesterol. J. Lab. Clin. Med 41: 486-492

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