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Vascular Endothelial Cadherin-mediated Cell-cell Adhesion Regulated by a Small GTPase, Rap1

  • Fukuhra, Shigetomo (Department of Structural Analysis, National Cardiovascular Center Research Institute) ;
  • Sakurai, Atsuko (Department of Structural Analysis, National Cardiovascular Center Research Institute) ;
  • Yamagishi, Akiko (Department of Structural Analysis, National Cardiovascular Center Research Institute) ;
  • Sako, Keisuke (Department of Structural Analysis, National Cardiovascular Center Research Institute) ;
  • Mochizuki, Naoki (Department of Structural Analysis, National Cardiovascular Center Research Institute)
  • Received : 2006.02.28
  • Published : 2006.03.31
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Abstract

Vascular endothelial cadherin (VE-cadherin), which belongs to the classical cadherin family, is localized at adherens junctions exclusively in vascular endothelial cells. Biochemical and biomechanical cues regulate the VE-cadherin adhesive potential by triggering the intracellular signals. VE-cadherin-mediated cell adhesion is required for cell survival and endothelial cell deadhesion is required for vascular development. It is therefore crucial to understand how VE-cadherin-based cell adhesion is controlled. This review summarizes the inter-endothelial cell adhesions and introduces our recent advance in Rap1-regulated VE-cadherin adhesion. A further analysis of the VE-cadherin recycling system will aid the understanding of cell adhesion/deadhesion mechanisms mediated by VE-cadherin in response to extracellular stimuli during development and angiogenesis.

Keywords

References

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