Food Science and Biotechnology

Korean Society of Food Science and Technology (한국식품과학회)
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Antimicrobial Effects of 8-Quinolinol

  • Kim, Young-Mi (Faculty of Biotechnology and Center for Agricultural Science and Technology, College of Agriculture, Chonbuk National University) ;
  • Jeong, Eun-Young (Faculty of Biotechnology and Center for Agricultural Science and Technology, College of Agriculture, Chonbuk National University) ;
  • Lim, Jeon-Hyeon (Faculty of Biotechnology and Center for Agricultural Science and Technology, College of Agriculture, Chonbuk National University) ;
  • Lee, Hoi-Seon (Faculty of Biotechnology and Center for Agricultural Science and Technology, College of Agriculture, Chonbuk National University)
  • Published : 2006.10.30
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Abstract

8-Quinolinol and other quinolinol derivatives were evaluated with regard to their growth-inhibitory effects against intestinal bacteria, using the paper disk-agar diffusion method. The observed growth responses varied according to the chemicals and dosages used, as well as the bacterial species tested. 8-Quinolinol showed a significant inhibitory effect against Clostridium difficile, C. perfringens, and Escherichia coli, at 5, 2, 1, and 0.5 mg/disk, and also exhibited a very strong inhibitory effect at 0.25 mg/disk. At low concentrations, 8-quinolinol had strong inhibitory effects against C. perfringens at 0.1 and 0.05 mg/disk; 8-quinolinol also manifested a moderate inhibitory effect against C. perfringens at 0.025 mg/disk. Furthermore, 8-quinolinol revealed moderate and weak growth inhibition against C. difficile and E. coli at concentrations of 0.1 and 0.05 mg/disk, respectively, but 2-quinolinol, 4-quinolinol, and 6-quinolinol evidenced no growth inhibition against B. bifidum, B. longum, C. difficile, C. perfringens, E. coli, or L. casei. The inhibitory effects of 8-quinolinol against C. difficile, C. perfringens, and E. coli lead to its consideration as a possible therapeutic modality for the treatment of diseases associated with harmful intestinal bacteria.

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References

  1. Bunting M, Lorant DE, Bryant AE, Zimmerman GA, McIntyre TM, Stevens DL, Prescott SM. Alpha toxin from Clostridium perfringens induces proinflammatory changes in endothelial cells. J. Clin. Invest. 3: 565-574 (1997) https://doi.org/10.1172/JCI100101
  2. Kim MK, Kim YM, Lee HS. Growth-inhibiting effects of Juniperus virginiana leaf-extracted components toward human intestinal bacteria. Food Sci. Biotechnol. 14: 164-167 (2005)
  3. Goldman P. Biochemical pharmacology and toxicology involving the intestinal flora. pp. 241-263. In: Human Intestinal Microflora in Health and Disease. Hentges DJ (ed). Academic Press, New York, NY, USA (1983)
  4. Mitsuoka T, Emeritus P. The human gastrointestinal tract. Volume I, pp. 68-78. In: The Lactic Acid Bacteria: The Lactic Acid Bacteria in Health and Disease. Wood BJB (ed). Elsevier Science Publishers, London, UK (1992)
  5. Hentges DJ. Role of the intestinal microflora in host defense against infection. pp. 311-331. In: Human Intestinal Microflora in Health and Disease. Hentges DJ (ed). Academic Press, New York, NY, USA (1983)
  6. Perdigon G, Alvarez S, Rachid M, Aguero G, Gobbato N. Immune system stimulation by probiotics. J. Dairy Sci. 78: 1597-1606 (1995) https://doi.org/10.3168/jds.S0022-0302(95)76784-4
  7. Kim YM, Lim MY, Lee HS. In vivo evaluation of potato varieties (Solanum tuberosum L.) on fecal microflora of human volunteers. Food Sci. Biotechnol. 14: 420-423 (2005)
  8. Cho JH, Lee CH, Lee HS. Antimicrobial activity of quinoline derivatives isolated from Ruta chalepensis toward human intestinal bacteria. J. Microbiol. Biotechn. 15: 646-651 (2005)
  9. Mitsuoka T. Bifidobacteria and their role in human health. J. Ind. Microbiol. 6: 263-268 (1990) https://doi.org/10.1007/BF01575871
  10. Benno Y. Effect of diets on human fecal microflora. Bifidus 4: 1-8 (1990)
  11. Mallett AK, Rowland IR, Beame CA, Flynn JC, Fehilly BJ, Udeen S, Farthing MJG. Effect of dietary supplements of apple pectin, wheat bran or fat on the enzyme activity of the human fecal flora. Microb. Ecol. Health D. 1: 23-32 (1988) https://doi.org/10.3109/08910608809140175