Journal of Korean Society of Occupational and Environmental Hygiene (한국산업보건학회지)

Korean Industrial Hygiene Association (한국산업보건학회)
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Study of correlation between airborne benzene and urinary trans,trans-muconic acid in Petrochemical industry processes

공기 중 벤젠과 소변 중 뮤콘산과의 상관성 연구

  • Joo, Kui Don (Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency) ;
  • Lee, Jong Seong (Center for Occupational Lung Diseases, Workers Accident Medical Corporation) ;
  • Choi, Seong Bong (Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency) ;
  • Shin, Jae Hoon (Center for Occupational Lung Diseases, Workers Accident Medical Corporation)
  • 주귀돈 (한국산업안전공단 산업안전보건연구원) ;
  • 이종성 (산재의료관리원 직업성폐질환연구소) ;
  • 최성봉 (한국산업안전공단 산업안전보건연구원) ;
  • 신재훈 (산재의료관리원 직업성폐질환연구소)
  • Received : 2006.09.11
  • Accepted : 2006.11.28
  • Published : 2006.12.31
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Abstract

To investigate the exposure effect of benzene, we measured airborne benzene as external doses, uninary tt-muconic acid as an internal dose of benzene exposure and analyzed the relationship between tt-muconic acid concentration and benzene exposure. The study population of eight businesses included 157 workers(87 workers in field; exposure group, 70 workers in board; control group) who produce or use benzene in petrochemical industry. The concentrations of airborne benzene were evaluated by personal samples and urine was sampled at the pre and end shift. Urinary t,t-muconic acid as internal dose was to analyze the relationship with airborne benzene. The geometric means(GM) of airborne benzene was 0.0231 ppm(range ND-1.0471 ppm) in exposure group and 0.0147 ppm(range ND-0.3162 ppm) in control group. The geometric means(GM) of urinary t,t-muconic acid at end-shift was $196.8{\pm}2.23{\mu}g/g$ creatinine in exposure group and $149.2{\pm}2.08{\mu}g/g$ creatinine in control group. There was significant correlation between the airborne concentration of benzene and the urinary concentration of t,t-muconic acid( r=0.711, p<0.01). From the results of stepwise multiple regression analysis about t,t-muconic acid at end-shift, significant independents was airborne benzene. In this study, there were significant correlation between the urinary concentration of t,t-muconic acid and the airborne concentration of benzene. More extensive studies ruling out healthy worker effect is needed.

Keywords

References

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