Clinical and Experimental Pediatrics

대한소아청소년과학회 (The Korean Pediatric Society)
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Immune thrombocytopenic purpura(ITP)

  • 신희영 (서울대학교 의과대학 소아과학교실)
  • Shin, Hee Young (Department of Pediatrics, Seoul National University College of Medicine)
  • 투고 : 2006.06.01
  • 심사 : 2006.07.01
  • 발행 : 2006.08.15
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초록

Immune thrombocytopenic purpura(ITP) is an autoimmune disease characterized by increased peripheral platelet destruction due to antibody to platelet, which results in thrombocytopenia and cutaneous or mucosal bleeding. Bleeding generally occurs when platelet counts fall to less than $20,000/{\mu}L$. Children affected with ITP are usually healthy prior to the onset of the disease and typically present suddenly after a viral infection or insidiously with progressive petechiae, bruising, or purpura. In most cases the disease is self-limited; approximately 80% of children recover by 6 months after diagnosis, with or without treatment. Children with thrombocytopenia persisting for more than 6 months are defined as having chronic ITP. Clinical manifestations, diagnosis, laboratory findings, differential diagnosis and various treatment modalities are reviewed.

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참고문헌

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