Clinical and Experimental Pediatrics

대한소아청소년과학회 (The Korean Pediatric Society)
권호 표지

반복되는 폐렴으로 내원한 청소년기 폐 칼시노이드 종양

Pulmonary carcinoid tumor presented with recurrent pneumonia in adolescence

  • 박은실 (경상대학교 의과대학 소아과학교실) ;
  • 박지숙 (경상대학교 의과대학 소아과학교실) ;
  • 서지현 (경상대학교 의과대학 소아과학교실) ;
  • 임재영 (경상대학교 의과대학 소아과학교실) ;
  • 이정희 (경상대학교 의과대학 병리학교실) ;
  • 고경혁 (경상대학교 의과대학 병리학교실)
  • Park, Eun Sil (Department of Pediatrics, Gyeonsang National University College of Medicine) ;
  • Park, Ji Suk (Department of Pediatrics, Gyeonsang National University College of Medicine) ;
  • Seo, Ji-Hyeon (Department of Pediatrics, Gyeonsang National University College of Medicine) ;
  • Lim, Jae Young (Department of Pathology, Gyeonsang National University College of Medicine) ;
  • Lee, Joung Hee (Department of Pathology, Gyeonsang National University College of Medicine) ;
  • Ko, Gyung Hyuck (Department of Pathology, Gyeonsang National University College of Medicine)
  • 투고 : 2006.02.08
  • 심사 : 2006.04.03
  • 발행 : 2006.07.15
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초록

소아의 기관 내 종양은 발생 빈도가 매우 낮고 그 증상이 소아에서 흔한 양성 호흡기 질환의 증상과 유사하여 진단 지연의 원인이 되기도 한다. 저자들은 동일 부위의 반복되는 폐렴으로 내원한 15세 여아에서 기관지 내시경을 통하여 기관 내 종양을 발견하고 병리 조직 검사를 통하여 전형적인 칼시노이드 종양을 진단하였기에 보고하는 바이다. 병리조직학적으로 전형적인 칼시노이드 종양은 수술적 절제만으로 완치를 기대할 수 있으나 원격 전이가 가능하기 때문에 장기간에 걸친 세심한 추적 검사가 필요하다.

The incidence of endobronchial tumor in the pediatric period is very rare and the symptoms are very close to those of respiratory tract infection. Diagnosis can be delayed because of low clinical suspicion and the many ways in which these tumors can present. We report the first case, in Korea, of a pulmonary carcinoid tumor that presented with recurrent pneumonia at the same location in adolescence. Treatment is surgical and geared towards complete resection while sparing healthy lung parenchyma. Long-term and careful follow up is recommended to detect local and distant metastasis.

키워드

참고문헌

  1. Quaedvlieg PF, Visser O, Lamers CB, Janssen-Heijen ML, Taal BG. Epidemiology and survival in patients with carcinoid disease in the Netherlands. An epidemiological study with 2391 patients. Ann Oncol 2001;12:1295-300 https://doi.org/10.1023/A:1012272314550
  2. Moertel CL, Weiland LH, Telander RL. Carcinoid tumor of the appendix in the first two decades of life. J Pediatr Surg 1990;25:1073-5 https://doi.org/10.1016/0022-3468(90)90221-T
  3. Soga J : Statistical evaluation of 2001 carcinoid cases with metastases, collected from the literature : A comparative study between ordinary carcinoids and atypical varieties. J Exp Clin Cancer Res 1998;17:3-12
  4. Travis WD, Rush W, Flieder DB, Falk R, Fleming MV, Gal AA, et al. Survival analysis of 200 pulmonary neuroendocrine tumors with clarification of criteria for atypical carcinoid and its separation from typical carcinoid. Am J Surg Pathol 1998;22:934-44 https://doi.org/10.1097/00000478-199808000-00003
  5. Granberg D, Wilander E, Oberg K, Skogseid B. Prognostic markers in patients with typical bronchial carcinoid tumors. J Clin Endocrinol Metab 2000;85:3425-30 https://doi.org/10.1210/jc.85.9.3425
  6. Hancock BJ, Di Lorenzo M, Youssef S, Yazbeck S, Marcotte JE, Collin PP. Childhood primary pulmonary neoplasm. J Pediatr Surg 1993;23:1133-6
  7. Al-Qahtani AR, Di Lorenzo M, Yazbeck S. Endobronchial tumors in children : institutional experience and literature review. J Pediatr Surg 2003;38:733-6 https://doi.org/10.1016/jpsu.2003.50195
  8. Spunt SL, Pratt CB, Rao BN, Pritchard M, Jenkins JJ, Hill DA, et al. Childhood carcinoid tumors : The St Jude Children's Research Hospital experience. J Pediatr Surg 2000; 35:1282-6 https://doi.org/10.1053/jpsu.2000.9297
  9. Hage R, de la Riviere AB, Seldenrijk CA, van den Bosch JM. Update in pulmonary carcinoid tumors : A review article. Ann Surg Oncol 2003;10:697-704 https://doi.org/10.1245/ASO.2003.09.019
  10. Lack E, Harris G, Eraraklis AJ, Vawter GF. Primary bronchial tumors in childhood. Cancer 1983;51:492-7 https://doi.org/10.1002/1097-0142(19830201)51:3<492::AID-CNCR2820510322>3.0.CO;2-W
  11. Granberg D, Sundin A, Janson ET, Oberg K, Skogseid B, Westlin JE. Octreoscan in patients with bronchial carcinoid tumors. Clin Endocrinol 2003;59:793-9 https://doi.org/10.1046/j.1365-2265.2003.01931.x