Journal of Pharmacopuncture (대한약침학회지)

KOREAN PHARMACOPUNCTURE INSTITUTE (대한약침학회)
권호 표지
DOI QR코드

DOI QR Code

소자약침(蘇子藥鍼)의 천식억제(喘息抑制) 및 면역조절효과(免疫調節效果)에 대(對) 실험적(實驗的) 연구(硏究)

  • Ko, Seung-Kyoung (Department of Acupunture & Moxibustion, Oriental Medical Hospital, Daejeon University) ;
  • Hong, Kwon-Eui (Department of Acupunture & Moxibustion, Oriental Medical Hospital, Daejeon University)
  • 고승경 (대전대학교 부속한방병원 침구과) ;
  • 홍권의 (대전대학교 부속한방병원 침구과)
  • Published : 2006.12.31
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives : The purpose of this study was to confirm the suppressive effect against asthma and immune regulatory effect of Perillae Fractusher Herbal-acupuncture at Chok-samni(ST36) on ovalbumin-induced asthma in mice. Methods : C57BL/6 mice were sensitized and challenged with OVA(ovalbumin) for 12 weeks. The mice in the PF-HA group were treated with PF-HA at ST36 for the later 8 weeks(3 times a weeks). The mice in the OVA-Needle-Prink(NP) group were treated with single prick with an injection needle at ST36 for the later 8 weeks(3 times a weeks). Results : 1. The lung weight of the mice treated with PF-HA at St36 were decreased significantly compared with that of the control group. 2. The total leukocytes and eosinophils in BALF of the group treated with PF-HA were decreased significantly compared with those of the control group. 3. Eosinophils in BALF and the collagen accumulation in lung of the mice treated with PF-HA were decreased significantly compared with those of the control group. 4. The Concentrations of IgE, IL-4 and IL-5 in BALF, and IL-4, IL-5 and IL-13 in serum of the PF-HA group were decreased significantly compared with those of the control group. 5. The numbers of CD3-/CCR3+, Gr-1+/CD11b+,CD4+, and CD3e+/CD69+cells in lung of the mice group treated with PF-HA at St36 were decreased significantly compared with those of the control group. 6. The mRNA expressions of TNF-${\alpha}$, IL-4, IL-5, IL-13 in lung of the mice group treated with PF-HA at St36 were decreased significantly compared with those of the control group.

Keywords

References

  1. E. Braunwald 외 : HARRISON'S 내과학. 서울:정담. 2003. : 1500-4.
  2. 양은석. 천식에서의 I1-4/IL-13 사이토카인 및 수용체. 소아알레르기 및 호흡기학회지. 2005; 15(1):1-11.
  3. Chiang DJ, Ye YL, Chen WL, Lee YL, Hsu HY, Chiang BL: Ribavirin or CpG DNA sequencemodulated dendritic cells decrease the IgE level and airway inflammation. Am J Respir Crit care Med. 2003 ; 168(5) : 575-80. https://doi.org/10.1164/rccm.2205005
  4. 최준호, 박성우, 장안수, 이준혁, 김도진, 박종숙, 박춘식, 장희경, 안미현, 민지원. 호산구성 기관지염과 천식의 객담내 IL-5과 IL-3의 기도 과민성과의 연관성. 천식 및 알레르기학회지. 2005; 25(3): 210-6.
  5. 李珩九, 鄭昇杞 : 東醫肺系內科學, 서울: 民瑞出版社. 1999: 187-202,426,460-1,468.
  6. 전국의과대학교수 역. 오늘의 진단 및 치료. 서울 : 한우리. 1999 : 287-97.
  7. 최병휘. 기관지 천식의 장기간의 치료원칙. 대학내과학회지. 2003; 64(4): 374-87.
  8. 황영실. 중증 기관지 천식의 치료. 대한내과학회지. 2004; 67(2):440-7.
  9. 楊維傑編. 黃帝內經譯解, 서울:一中社. 1991:67-73, 235-43.
  10. 朱震亨. 丹溪醫集: 서울대학교 출판부. 서울. 2000 : 261-4.
  11. 박양춘. 蘇子降氣湯과, 加味蘇子降氣湯이 I형 및 IV형 알레르기 반응과 肺損傷에 미치는 영향. 大田大學校大學院. 1994.
  12. 김상찬, 변성희. 백화사설초(白花蛇舌草)가 ovealbumin으로 유도된 천식동물모델에서 Eosinophil의 수, IgE및 IL-4에 미치는 영향. 대한본초학회지(본초분과학회지). 2005; 20(2) : 35-42.
  13. 김재흥. 冬蟲夏草 藥鍼과 口腔投與가 ovalbumin으로 유발된 Asthma에 미치는 영향. 대한침구학회지. 2002 ; 19(2) : 39-50.
  14. 全國韓醫科大學 鍼灸經穴學敎室 : 鍼灸學(上,下), 서울 : 集文堂. 1991 : 382-4.
  15. 李丁. 鍼灸經穴辭典, 서울 : 高麗醫學. 1989: 138-9, 397-8.
  16. Teculescu D. Clear defunitions of chronic bronchopulmonary disease : a necessary for practice, teaching and research in pneumology. Rev Pneumol Clin. 1990;46 : 194-199.
  17. Sly RM. Continuing decreases in asthma mortality in theUnited State. Ann Allergy Asthma Immunol. 2004 ; 92: 313-318. https://doi.org/10.1016/S1081-1206(10)61568-2
  18. Jeffery PK. Remodeling in asthma and chronic obstructive lung disease. am J Respir Crit Med. 2001 ; 164: 28-38. https://doi.org/10.1164/ajrccm.164.supplement_2.2106061
  19. Bukantz SC. Clemens von Pirquet and the concept of allergie. J Allergy Clin Immnunol. 2002 ; 109 : 724-726.
  20. 김미경. 비염, 부비동염과 천식. 대한내과학회지. 2003; 65(2) : 546-548.
  21. 박용민. 기관지 천식의 최신지견. 소아알레르기 및 호흡기. 2004 ; 14(4) : 306-323.
  22. 丁奎萬. 알레르기와 韓方. 서울:도서출판 第一路, 1993:59-89.
  23. Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention. : National Heart, Lung, and Blood Institute, National Institutes of Health. 2002.
  24. 虞搏編. 醫學正傅. 서울:도서출판 성보사. 1986 : 101-4.
  25. 李中梓. 醫宗必讀. 서울: 일중사. 1991 : 303-8.
  26. 張介賓. 景岳全書(上). 서울: 일중사. 1984: 344-9.
  27. 전국한의과대학 폐계내과학교실. 東醫肺系內科學. 서울: 도서출판 한문화사. 200:192-9.
  28. 申佶求. 申氏本草學. 서울: 수문사. 1988:484-5.
  29. 全國內科大學 本草學敎室編著. 本草學. 서울:永林社. 1999 : 483-4.
  30. 金定濟. 最新鍼灸學. 서울:성보사. 1979: 405.
  31. 崔晈變. 水針療法에 關한 考察. 대한한의학회지. 1990; 11(1) : 315-324.
  32. 송영호. 白屈菜分劃藥鍼이 抗癌 및 免疫反應에 미치는 影響. 大田大學校大學院. 1997.
  33. 정영돈. 足三里에 시술한 旱蓮草藥鍼의 免疫增進과 抗癌작용에 관한 硏究. 大田大學校大學院. 2003.
  34. 신성찬. 桑葉藥鍼이 喘息抑制效果에 대한 實驗的 硏究. 大田大學校大學院. 2004.
  35. 하대유. 그림으로 본 면역학. 서울 : 고문사. 1994. 279-330.
  36. Ivan Roitt. Immunology 6th. NewYork:Mosby. 2002 : 125-7.
  37. Stirling RG, Van Rensen EL, Barnes PJ, Chung KF. Interleukin-5 induces CD34+eosinophil progenitor mobilization and eosinophil CCR3 expression in asthma. Am J Respir Crit Care Med. 2001 ; 164 : 1403-1409. https://doi.org/10.1164/ajrccm.164.8.2010002
  38. Van Rensen EL, Stirling RG, Scheerens J, Staples K, Sterk PJ, Barnes PJ, et al. Evidence for systemic rather than pulmonary effects of interleukin-5 administration in asthma. Thorax. 2001 ; 56: 935-940. https://doi.org/10.1136/thorax.56.12.935
  39. 김세종. 면역학. 서울:고려의학. 1994: 3, 8, 25-6, 28,31-2.
  40. Nicholas W. Lukacs. Role of chemokines in the pathogenesis of asthma. Nature review. Immunology. 2000; 1: 108-16 https://doi.org/10.1038/35100503