Journal of Pharmacopuncture (대한약침학회지)

KOREAN PHARMACOPUNCTURE INSTITUTE (대한약침학회)
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처치온도에 따른 초미분화 산양삼의 홍삼화 연구

  • Kim, Jin-Ho (Dept. of Acupuncture & Moxibustion, Oriental Medical College, Sangji University) ;
  • Kwon, Ki-Rok (Dept. of Acupuncture & Moxibustion, Oriental Medical College, Sangji University) ;
  • Lee, Eun-Hee (Devision of Animal resourses and life science, Sangji University) ;
  • Cha, Bae-Chun (Devision of Animal resourses and life science, Sangji University)
  • 김진호 (상지대학교 한의과대학 침구학교실) ;
  • 권기록 (상지대학교 한의과대학 침구학교실) ;
  • 이은희 (상지대학교 동물생명자원학부) ;
  • 차배천 (상지대학교 동물생명자원학부)
  • Published : 2006.12.31
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Abstract

Objectives : The aim of this study was to find optimal conditions for producing red ginseng from cultivated wild ginseng using the Turbo Mill. Methods : Characteristics of powdered cultivated wild ginseng based on various temperature settings of the Turbo Mill were observed, and changes in the content was measured by HPLC for various ginsenosides. Results : 1. The diameter of cultivated wild ginseng powder ground by the Turbo Mill was around 10${\mu}m$. 2. As the temperature rose, pressure, Specific Mechanical Energy(SME), and density decreased, whileas Water Solubility Index(WSI) increased. 3. As the temperature rose, super fine powder showed tendency to turn into dark brown. 4. Measuring content changes by HPLC, there was no detection of ginsenoside Rg3 and ginsenosideRg1, Rb1, and Rh2 concentrations decreased with increase in temperature. Conclusions : Super fine powder of cultivated wild ginseng produced by the Turbo Mill promotes easy absorption of effective ingredients by breaking the cell walls. Using this mechanism to produce red ginseng from cultivated wild ginseng, it yielded less than satisfactory results under the current experiment setup. Further researches are needed to verify more suitable condition for the production of red ginseng.

Keywords

References

  1. 신순식. 산삼 감정 기준의 객관성. 한의학연구소 동의 한의연 제 5집. 2001 ; 107-114.
  2. Chang HK. Effect of processing methods on the chemical composition of Panax ginseng leaf tea. Korean J. Food Nutr. 2005 ; 18 : 63-71.
  3. Lim WS. Effects of interactions among age, cultivation method location and population on ginsenosides content of wild Panax quinquifolium L. one year after transplanting from wild. Korean J. Med. Crop Sci. 2005 ; 13 : 254-261.
  4. Wang W., Zhao Zi, Xu YF, Qian XH, Zhong JJ. Efficient elicitation of ginsenoside biosynthesis in cell cultures of Panax notoginseng by using self chemically synthesized jasmonates. Biotechnol. Bioprocess Eng 2005 ; 10 : 162-265. https://doi.org/10.1007/BF02932587
  5. Ko SK, Lee CR, Choi YE, Im BO, Sung JH, Yoon KR. Analysis of ginsenosides of white and red ginseng concentrates. J. Korean Food Sci. Technol. 2003 ; 35 : 536-539.
  6. Kim YS, Jin SH. Ginsenoside-Rh2 induces apoptosis via activation of caspase-1 and up-regulation of bax in human neuroblastoma. Arch. Pharm. Res. 2004 ; 27 : 834-839. https://doi.org/10.1007/BF02980175
  7. Rauwendaal, C. Polymer extrusion. Hanser Publishers, New York, 1986 ; 22-55.
  8. Harper, J.M. Extrusion of Foods CRC Press. Boca Raton, FL. 1981 ; 3-6.
  9. 전국한의과대학 본초학교수 공편저. 본초학. 영림사. 1994 ; 531.
  10. 이상인. 한약임상응용. 성보사. 1982 ; 345-350.
  11. 하대유. 인삼에 대한 세포학 및 면역학적 연구, 대한면역학회지. 1979 ; 1(1) : 45-52.
  12. 山田昌之. 朝鮮人蔘의 硏究. 日本藥理學會誌 1955 ; 51 : 390.
  13. Brekhman, I.I. Panax ginseng, Gosudarst Isdat et Med. Lit. Leningard, 1957 ; 1
  14. 최진호. 인삼의 신비, 서울, 교문사, 1984 ; 13-14.
  15. 남기열. 최신 고려인삼, 천일인쇄소, 1996 ; 56.
  16. Takagi, K. Proceedings International Ginseng Symposium. The Central Research Institute. Office of Monopoly, Seoul, Korea, p.119. 1974.
  17. 김성진, 신순식, 서부일, 지선영. 산삼, 장뇌삼, 인삼의 항암효과에 대한 비교연구. 대한본초학회지. 2004 ; 19(2) : 41-50.
  18. 권기록, 조아라, 이선구. 정맥주입용 산양산삼 증류약침의 급성, 아급성 독성 실험 및 Sarcoma-180 항암효과에 관한 실험적 연구, 대한약침학회지. 2003 ; 6(2) : 7-27. https://doi.org/10.3831/KPI.2003.6.2.007
  19. 조희철, 이선구, 권록. 농도별 산양산삼 증류약침의 apoptosis 에 관한 실험적 연구, 대한약침학회지. 2004 ; 7(2) : 1-15. https://doi.org/10.3831/KPI.2004.7.2.005
  20. 곡경승, 이선구, 권기록. pH 및 전해질 조절 산양산삼 증류약침의 apoptosis에 관한 실험적 연구, 대한침구학회지. 2004 ; 21(6) : 1-17.
  21. Ki-Rok Kwon, Chi-Wan Park, Min-Soo Ra, Chong-Kwan Cho. Clinical Observation of Multiple Metastatic Cancer Patient with Hepatocellular Carcinoma treated with Cultivated Wild Ginseng Herbal Acupuncture Therapy. J. of Korean Acupuncture & Moxibustion Society, 2005 ; 22(2) : 211-217.
  22. 권기록. 정맥주입용 산삼약침이 인체에 미치는 영향에 관한 임상적 연구, 대한약침학회지. 2004 ; 7(1) : 15-26.
  23. 권기록, 윤휘철, 김 호연. B16/F10 세포를 이식한 C57/BL6 생쥐에서 산삼약침의 항암효과 및 Doxorubicin에 의한 생식독성 완화효과. 대한침구학회지. 2006 ; 23(1) : 105-120.
  24. Nam, K.Y. Recently Korean ginseng(Components and efficiency). Korean ginseng tobacco Institute, 1996 ; 225-253.
  25. 하대철, 이종원, 김나미, 류기형. 배럴온도와 스크루 회전속도에 따른 압출성형 수삼의 특성. J. Ginseng Res 2005 ; 29(2) : 107-112. https://doi.org/10.5142/JGR.2005.29.2.107
  26. Lee BG, Jeong YH, Cho DH, Lee KY, Kang WS. Super Fine Powerization of Ginseng Using Low Temporature Turbo Mill. Key Engineering Materials 2006 ; 326-328 :445-448. https://doi.org/10.4028/www.scientific.net/KEM.326-328.445
  27. Ko, S. R., Choi, K. J., Kim, S. C., Han, K. H. Content and composition of saponin compounds of Panax species. Korean J. Ginseng Sci 1995 ; 19 : 254-295.
  28. Morita, T. Chemical studies on Panax genus plants grown in Asia. Hiroshima univ. Doctoral Thesis, 6-7(1986).
  29. Fuzzati, N., Gabetta, B., Jayakar, K., Pace, R., Peterlongo, F. Liquid chromatography-electrospray mass spectrometric identification of ginsenosides in Panax ginseng roots. J. Chromatogr., 854 : 69-79(1999). https://doi.org/10.1016/S0021-9673(99)00463-X
  30. Wang, H., Zou, H., Kong, L., Zhang, Y., Pang, H., Su, C., Liu, G., Hui, M., Fu, Li. Determination of ginsenoside Rg3 in plasma by solid-phase extraction and high-performance liquid chromatography for pharmaco-kinetic study. J. Chromatogr., 731 : 403-409(1999) https://doi.org/10.1016/S0378-4347(99)00238-8
  31. Kwon, S. W., Han, S. B., Park, I. H., Kim, J. M., Park, M. K., Park, J. l. Liquid chromatographic determination of less polar ginsenosides in processed ginseng. J. Chromatogr., 921 : 335-339(2001). https://doi.org/10.1016/S0021-9673(01)00869-X
  32. 양승준, 우관식, 유정식, 강태수, 노영희, 이준수, 정헌상. 고온고압처리에 의한 인삼의 성분 변화. J. Korean Food Sci. Technol 2006 ; 38(4) : 521-525.