Journal of Oral Medicine and Pain

Korean Academy of Orofacial Pain and Oral Medicine (대한안면통증구강내과학회)
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Clinical Effect of Avocado/Soybean Unsaponifiables on Osteoarthritis of the Temporomandibular Joint

측두하악관절의 골관절염 치료에서 Avocado/Soybean Unsaponifiables의 효용성

  • Kim, Hee-Jin (Department of Dentistry, College of Dentistry, Pusan National University) ;
  • Park, June-Sang (Department of Dentistry, College of Dentistry, Pusan National University) ;
  • Ko, Myung-Yun (Department of Dentistry, College of Dentistry, Pusan National University) ;
  • Ahn, Yong-Woo (Department of Dentistry, College of Dentistry, Pusan National University)
  • 김희진 (부산대학교 치과대학 구강내과학 교실) ;
  • 박준상 (부산대학교 치과대학 구강내과학 교실) ;
  • 고명연 (부산대학교 치과대학 구강내과학 교실) ;
  • 안용우 (부산대학교 치과대학 구강내과학 교실)
  • Published : 2006.06.30
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Abstract

The aim of this study was to investigate the beneficial effect of a daily dose of 300 mg of ASU taken for more than 3 months on the subjects diagnosed as osteoarthritis of temporomandibular joint by RDC/TMD. Total 68 outpatients(15-54y) of female except menopause in Orofacial Pain Clinics of the Pusan National University Hospital were randomly assigned to either an ASU group(n=36) or a placebo group(n=32). The pain, noise and limited mouth opening(LOM) were evaluated by numerical analogue scale(NAS, range 0-10) and maximum comfortable opening(MCO) were measured by milimeter scale. The difference of simple uptake rate(SUR) on bone scan, hot spot(HS) on coronal SPECT, condylar bony changes on CT between the ASU and placebo groups were compared to investigate the objective effect. The obtained results were as follows. 1. Comparison of the NAS of pain, noise, LOM and MCO before treatment and 3, 6 and 9 months after treatment showed no significant difference between the ASU and placebo groups. 2. Comparison of the NAS of pain, noise, LOM and MCO before treatment and 3, 6 and 9 months after treatment showed no significant difference between the ASU and placebo groups without splint treatment, but showed more increased MCO in the ASU group than the placebo group with splint treatment at 6, 9 months after treatment. 3. Comparison of the NAS of pain before treatment and 3, 6 and 9 months after treatment that the NAS of pain at first visit divided into two groups(above or below 6) showed more decreased the NAS of pain in the ASU group than the placebo group that the NAS of pain at first visit was above 6. 4. Comparison of the NAS of pain, noise, LOM and MCO during 6 months period showed improvement of clinical symptoms within group, but no significant difference between subjects. 5. The simple uptake ratio(SUR) on bone scan and hot spot(HS) on coronal SPECT showed more increased SUR and HS in affected side than non-affected side of the ASU and placebo groups. 6. Comparing of condylar bony changes, osseous remodeling were observed highest, osteophyte lowest in the affected and non-affected side of the two groups. After treatment, comparison of condylar bony changes were observed more decreased erosive features in the ASU group than the placebo group.

본 연구는 2003년 10월부터 2006년 3월까지 부산대학교 병원 구강내과 구강안면통증클리닉에 내원하여 RDC/TMD에 의해 측두하악관절의 골관절염으로 진단된 환자 중 본 실험에 동의한 폐경기가 오지 않은 여성 환자를 무작위로 나누어, 주기적 내원 하에 실제로 ASU 300 mg을 연속 복용한 ASU군(총 36명)과 ASU와 동일한 제재이지만 약효가 없는 약물을 복용한 위약군(총 32명)으로 분류하여 ASU를 장기간 투여시 통증, 관절음, 개구제한(LOM), 무통성 편이 개구량(MCO)의 변화뿐만 아니라 골스캔의 단순섭취율(SUR), coronal SPECT상에서의 온점개수(HS), 그리고 CT상에서의 과두 관절면의 비교시 다음과 같은 결과를 얻었다. 1. ASU군과 위약군의 치료 전, 치료 3개월 후, 치료 6개월 후, 치료 9개월 후의 무통성 편이개구량(MCO)과 통증, 관절음, 개구제한(LOM)의 NAS를 비교시 두 군간의 유의한 차이가 없었다. 2. ASU군과 위약군의 치료 전, 치료 3개월 후, 치료 6개월 후, 치료 9개월 후의 MCO를 비교시 장치치료를 시행하지 않은 두 군간에서는 유의한 차이가 없었다. 그러나, 장치치료를 시행한 ASU군에서 위약군에 비해 치료 6개월 후, 치료 9개월 후에 MCO가 더 증가하는 경향을 보였다. 3. ASU군과 위약군을 초진시 통증에 대한 NAS가 6미만인 경우와 6이상인 경우로 분류하여 치료 전, 치료 3개월 후, 치료 6개월 후, 치료 9개월 후를 비교시 두 군 모두 치료 3개월 후, 치료 9개월 이후에 통증이 더 감소하며, 통증의 NAS가 6이상인 경우에서 ASU군이 위약군에 비해 통증이 더 감소하는 경향을 보여 주었다. 4. 주기적 내원하에 6개월간 약물치료를 시행한 ASU군(총19명)과 위약군(총 21명)의 MCO와 통증, 관절음, 개구제한의 NAS를 비교시 각 군내에서는 임상증상의 개선이 현저하였으나, 두 군간에서는 유의한 차이가 없었다. 5. ASU군과 위약군을 이환측과 비이환측으로 분류하여 측두하악관절의 골스캔의 단순섭취율(SUR)과 coronal SPECT상에서의 온점개수(HS)를 비교시 두 군 모두에서 이환측이 비이환측에 비해 단순섭취율과 온점개수 모두 높게 나타났으며, 단순섭취율과 온점개수는 상관관계를 보여주었다. 6. 이환 및 비이환 관절 모두에서 골재형성 반응이 가장 많이 관찰되었고, 골증식체는 가장 적게 관찰되었다. 치료전후의 ASU군(총 34부위)과 위약군(총 20부위)의 과두 관절면을 비교시 ASU군에서 보다 많은 침식소견의 감소경향을 보여주었다.

Keywords

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