Anti-wrinkle Effect of Morinda citrifolia (Noni) Extracts

노니 추출물의 주름개선 효과연구

  • 이정노 (코리아나 화장품 송파기술연구소) ;
  • 김상우 (코리아나 화장품 송파기술연구소) ;
  • 유영경 (코리아나 화장품 송파기술연구소) ;
  • 이강태 (코리아나 화장품 송파기술연구소) ;
  • 이건국 (코리아나 화장품 송파기술연구소)
  • Published : 2006.12.30

Abstract

Wrinkle formation is mainly attributed to the environmental factors such as UV rays, air pollution, smoking and stress etc. Especially, UV rays induce premature skin aging which is characterized by deep wrinkle, leathery dryness etc. Recently, researches on the wrinkle formation and its prevention have been the main theme in cosmetics fields. We have studied the various plant extracts having anti-wrinkle effects and finally showed that Noni (Morinda citrifolia) extracts have the efficacy of promoting the type I collagen synthesis in normal human fibroblast, using PICP assay. We purified one active compound from Noni extracts and identified its structure. It was identified as 6,7-Dimethoxy-2H-1-Benzopyran-2-one; scopoletin by $^1H-NMR,\;^{13}C-NMR,$ IR, Mass analysis. Scopoletin increased collagen synthesis in a dose dependent manner (89.5% at $0.2{\mu}g/mL$). In order to verify the anti-aging effectiveness of the cream containing 3% noni extracsts, we performed the in vivo test with some female volunteers for 12 weeks. It reduced the signs of aging, especially face wrinkles. From these results, we conclude that the noni extracts could be used as an useful anti-wrinkle agent.

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