Korean Journal of Human Ecology (한국가정과학회지)

The Korean Society of Human Ecology (한국가정과학회)
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The Effect of Stevia (Stevia. Rebaudian Bertoni) Extract Supplementation on Lipid Metabolism and Liver Function of Rats Administered with Ethanol

스테비아(Stevia. Rebaudian Bertoni)추출물 보강이 만성 알코올 섭취 흰쥐의 지질대사 및 간기능에 미치는 영향

  • Park, Jeong-Eun (Department of Food Science and Human Nutrition, Chonbuk National University) ;
  • Soh, Ju-Ryoun (Department of Food Science and Human Nutrition, Chonbuk National University) ;
  • Oh, Suk-Heung (Department of Biotechnology, Woosuk University) ;
  • Cha, Youn-Soo (Department of Food Science and Human Nutrition, Chonbuk National University)
  • 박정은 (전북대학교 식품영양학과) ;
  • 소주련 (전북대학교 식품영양학과) ;
  • 오석흥 (우석대학교 생명공학과) ;
  • 차연수 (전북대학교 식품영양학과)
  • Published : 2006.03.01
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Abstract

To investigate the effects of the supplementation of Stevia. Rebaudian Bertoni on serum and hepatic lipid levels and enzyme activities in rat administered with ethanol chronically. Sprague-Dawley male rats were orally treated with either an AIN-76 diet(C, control), a control diet plus ethanol(E, 4g/kg bw), E plus stevia extract-1(ES1, 1ml/kg bw), or E plus stevia extract-2(ES2, 2ml/kg bw) for 7 weeks. Serum triglyceride levels were increased in the E group and were decreased in the ES 1 group. Liver triglyceride levels were decreased significantly in the ES2 groups and Total-cholesterol were decreased in the ES1, ES2 groups compared with the E group. Liver $\gamma-GTP$ levels were decreased significantly in the ES1, ES2 groups compared with the E group. In addition, we have evaluated the serum or liver carnitine levels in those groups. Liver TCNE levels were increased significantly in the ES1, ES2 compared with the E group. These results may suggest that supplementation of Stevia. Rebaudian Bertoni has effects on the recovery of chronic ethanol-related diseases.

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