Correlation between Pulse-respiration Ratio and Heart Rate Variability

맥솔(脈率)과 심박변이도(心搏變移度)의 상관성(相關性) 연구(硏究)

Background : Pulse-respiration ratio has been used for estimating subject's status in oriental medicine. Pulse and respiration is strongly associated with autonomic nerve system. But there is no research about correlation between pulse-respiration ratio and autonomic nerve system. Objectives : We performed this study to know correlation between pulse-respiration ratio and HRV(heart rate variability) that shows autonomic nerve system status well and to clarify clinical meaning of pulse-respiration ratio. Methods : After subject's 10 minutes rest, we measured subject's ECG, respiration pattern and HRV. In this research, subject's number is 95(Male 50/Female 45). We calculated pulse-respiration ratio from ECG and respiration pattern. Then, we analyzed correlation between pulse-respiration ratio and HRV parameters in all subjects, 2 group divided by Wan-Maek(P-R ratio 4.28). We tried to compare HRV parameters among Wan-Maek, Sak-Maek and Ji-Maek group. Correlation analysis between pulse-respiration Ratio and Pulse rate, respiration rate is performed. Finally correlation analysis between Respiration and HRV parameters in all subjects, 2 group divided by Wan-Maek(4.28) is studied. Results : 1. Mean pulse-respiration is 4.10${\pm}$0.67, Mean pulse rate is 68.06${\pm}$7.82bpm, Mean respiration rate is 16.81${\pm}$2.72 times per minute in all subjects. 2. Correlation analysis between pulse-respiration ratio and HRV parameters of high pulse-respiration ratio group is not significant. But, in low pulse-respiration ratio group, HFnorm(correlation coefficient 0.306, p= 0.018), lnHF (0.308, p=0.002) is significantly correlated with pulse-respiration ratio. 3. Comparison of HRV parameters among Wan-Maek, Sak-Maek and Ji-Maek Group is not significant. 4. Pulse-respiration ratio is more affected by respiration rate(correlation coefficient-0.17, p=0.000) than pulse rate (correlation coefficient 0.396, p=0.000). 5. Correlation analysis between respiration rate and HRV parameters of high pulse-respiration ratio group is not significant. But, in low pulse-respiration ratio group, HFnorm (correlation coefficient -0.327, p=0.011), LF/HF(0.346, p=0.007), lnHF (-0.355, p=0.006) are significantly correlated with respiration rate. Conclusion : Pulse-respiration ratio and parasympathetic index has positive correlation. The closer Wan-Maek, The higher parasympathetic index in low pulse-respiration ratio group. Respiration rate is more related with pulse-respiration ratio than pulse rate. Respiration is negatively correlated with autonomic parameters. And the slower respiration, the higher parasympathetic index in low pulse-respiration ratio group.