Journal of Periodontal and Implant Science

Korean Academy of Periodontology (대한치주과학회)
권호 표지

The effects of Acellular dermal matrix on the healing of 1 wall intrabony defects in dogs

성견에서 Acelluar dermal matrix가 1면 골내낭 결손부의 치주조직 재생에 미치는 영향

  • Park, Ju-Un (Department of Periodontology, College of Dentistry, Chosun University, Oral Biology Research Institute, College of Dentistry, Chosun University) ;
  • Kim, Byung-Ock (Department of Periodontology, College of Dentistry, Chosun University) ;
  • Park, Joo-Cheol (Department of Oral Histology, College of Dentistry, Chosun University, Oral Biology Research Institute, College of Dentistry, Chosun University) ;
  • Jang, Hyun-Seon (Department of Periodontology, College of Dentistry, Chosun University, Oral Biology Research Institute, College of Dentistry, Chosun University)
  • 박주언 (조선대학교 치과대학 치주과학 교실, 조선대학교 치과대학 구강생물학연구소) ;
  • 김병옥 (조선대학교 치과대학 치주과학 교실) ;
  • 박주철 (조선대학교 치과대학 구강조직학 교실, 조선대학교 치과대학 구강생물학연구소) ;
  • 장현선 (조선대학교 치과대학 치주과학 교실, 조선대학교 치과대학 구강생물학연구소)
  • Published : 2006.03.30
Download PDF
⟨ Previous Next ⟩

Abstract

Although the main purpose of periodontal treatment to regenerate is the complete regeneration of periodontal tissue due to periodontal disease, most of the treatment cannot meet such purpose because healing by long epithelial junction. Therefore, diverse materials of resorbable and non-resorbable have been used to regenerate the periodontal tissue. Due to high risk of exposure and necessity of secondary surgical procedure when using non-resorbable membrane, guided tissue regeneration using the resorbable membrane has gain popularity, recently. However, present resorbable membrane has the disadvantage of not having sufficient time to regenerate date to the difference of resorption rate according to surgical site. Meanwhile, other than the structure stability and facile manipulation, acellular dermal matrix has been reported to be a possible scaffold for cellular proliferation due to rapid revascularization and favorable physical properties for cellular attachment and proliferation. The purpose of this study is to estimate the influence of acellular dermal matrix on periodontal ligament, cementum and alveolar bone when acellular dermal matrix is implanted to 1-wall alveolar bone defect. 4 dogs of 12 to 16 month old irrelevant to sex , which below 15Kg of body weight, has been used in this study. ADM has been used for the material of guided tissue regeneration. The 3rd premolar of the lower jaw was extracted bilaterally and awaited for self-healing. subsequently buccal and lingual flap was elevated to form one wall intrabony defect with the depth and width of 4mm on the distal surface of 2nd premolar and the mesial surface of 4th premolar. After the removal of periodontal ligament by root planing. notch was formed on the basal position. Following the root surface treatment, while the control group had the flap sutured without any treatment on surgically induced intrabony defect. Following the root surface treatment, the flap of intrabony defect was sutured with the ADM inserted while the control group sutured without any insertion. The histologic specimen was observed after 4 and 8 weeks of treatment. The control group was partially regenerated by periodontal ligament, new cementum and new alveolar bone. the level of regeneration is not reached on the previous formed notch. but, experimental group was fully regenerated by functionally oriented periodontal ligament fiber. new cementum and new alveolar bone. In conclusion, we think that ADM seems to be used by scaffold for periodontal ligament cells and the matrix is expected to use on guided tissue regeneration.

Keywords

References

  1. Melcher AH. On the repair potential of periodontal tissues. J Periodontol 1976;47:256-60 https://doi.org/10.1902/jop.1976.47.5.256
  2. Karring T, Nyman S, Gottlow J, Laurell L. Developement of the biological concept of guided tissue regeneration - animal and human studied. Periodontol 2000 1993;1:26-35 https://doi.org/10.1111/j.1600-0757.1993.tb00204.x
  3. Haney JM, Nilves RE, McMillan PJ, Wikesjo UME. Periodontal repair in dogs: Expanded polytetrafluoroethylene barrier membranes support wound stabilization and enhance bone regeneration. J Periodontol 1993;64:883-890 https://doi.org/10.1902/jop.1993.64.9.883
  4. Karring T., Nyman, S.& Lindhe, J. Healing following implantation of periodontitis affected roots into bone tissue. Journal of Clinical Periodontology 1980;12:51-60 https://doi.org/10.1111/j.1600-051X.1985.tb01353.x
  5. Gottlow J, Nyman S, Lindhe J, Karring T, Wennstrom J. New attachment formationin the human periodontium by guided tissue regeneration. Case reports. J Clin Periodontol 1986;13:604-616 https://doi.org/10.1111/j.1600-051X.1986.tb00854.x
  6. Wikesjo UME, Sigurdsson TJ. Guided Bone Regeneration: Is it a reproductible technique? J Parodontol Implantol Orale. 1994;13:243-257
  7. Blumenthal, N. M. A clinical comparison of collagen mambranes with e-PTFE menbranes in the treatment of human mandibular buccal class II furcation defects. Plast. Reconstr. Surg. 1988;81:772-676
  8. Schallhorn , R. G., and McClain, P. K. Combined osseous composite grafting root conditioning and guided tissue regeneration. Int. J. Periodont. Rest. Dent. 1988;8:24-31
  9. McGuire, M. K. Reconstruction of bone on facial surfaces A series of case report. Int. J. Periodnt. Rest. Dent. 1992;12:133-144
  10. McClain, P. K., and Schallhorn, R. G. Composite grafting root conditioning and guided tissue regeneration. Int. J. Periodont. Rest. Dent. 1993;13:9-27
  11. Galgut, P., Pitrola., R., Waite, I., Doyle, C., and Smith, R. Histological evaluation of biodegradable and non-degradable membrane placed transcutaneously in rats. J. Clin. Periodontol. 1991;18: 581-586 https://doi.org/10.1111/j.1600-051X.1991.tb00093.x
  12. Laurell, L., Falk, H. Formell, J., Johard, G., and Gottlow, J. Clinical use of a bioresorbable matrix barrier in guided tissue regeneration therapy. Case series. J. Periodontol. 1994;65:967-975 https://doi.org/10.1902/jop.1994.65.10.967
  13. Hutmacher, D., Hurzeler, M. B. and Schliephake, H. A review of material properties of biodegradable polymers and devices for GTR and GBR applications. Int. J. Maxillofac. Implant. 1996;11:667-678
  14. Cortllini, P., Pini-pratp, G., and Tonetti, M. S. Periodontal regeneration of human intrabony defects with bioresorbable membranes. A controlled clinical trial. J. Periodontol. 1996;67:217-223 https://doi.org/10.1902/jop.1996.67.3.217
  15. Becker, W., Becker, B. E., Mellonig, J., Caffesse, R.G., Warrer, K., Caton, J.G., and Reid, T. A prospective multi-center study evaluating periodontal regeneration for class II furcation invasion and intrabony defects after treatment with a bioresorbable barrier membrane : 1 year results. J. Periodontol. 1996;67:641-649 https://doi.org/10.1902/jop.1996.67.7.641
  16. Cheo JM, Kothandapani R, James L, Bowling D., Autologous, cadaveric and synthetic materials used in sling surgery: Comparative biomechanical analysis. Urology. 2001;58:482-486 https://doi.org/10.1016/S0090-4295(01)01205-5
  17. Buinewicz B, Rosen B. Acellular cadaveric dermis(AlloDerm) : A new alternative for abdominal hernia repair.' Ann Plast Surg 2004;52:188-194 https://doi.org/10.1097/01.sap.0000100895.41198.27
  18. Menon NC, Rodriguez ED, Bymes CK, Girotto JA, Goldberg NH, Siverman RP. Revascularization of human acellular dermis in full-thickness abdominal wall reconstruction in the rabbit model. Ann Plast Surg 2003;50:523-527 https://doi.org/10.1097/01.SAP.0000044252.76804.6B
  19. Siverman RP, Singh NK, Li EN, Disa JJ, Girotto JA, Slezak S, Goldberg NH. Ventral hernia repair using allogenic acellular dermal matrix in a swine model. Hernia 2004;8:336-342 https://doi.org/10.1007/s10029-004-0241-6
  20. Burler CE, Prieto VG. Reduction of adhesions with composite AlloDerm/polypropylene mesh implants for abdominal wall reconstruction. Plast Reconstr Surg 2004;114:164-473 https://doi.org/10.1097/01.PRS.0000124425.17493.D3
  21. Buinewicz B. The use of human acellular tissue matrix in abdominal wall reconstruction. A clinical perspective. LifeCell Clinical Monograph Series. 2003
  22. Kaleya RN. Use of a global economic model to analyze the cost-benefit of AlloDerm in ventral hernia repair. LifeCell Clinical Monograph Series. 2005
  23. Ng KW,Khor HL,Hutmacher DW. In vitro characterization of natural and synthetic dermal matrices cultured with dermal fibroblasts. Biomaterials 2004;14:2807-18
  24. Beniker D, McQuillan D. The use of acellular dermal matrix as a scaffold for periosteum replacement. Orthopedics 2003;5 suppl:s591-6
  25. Christopher R. Richardson, J. Gary Maynard Jr. A cellular dermal graft: A human histologic case report. Int J Periodontics Restorative Dent 2002;1:21-29
  26. Silverstein LH, Callan DP An acellular dermal matrix allograft substitute for palatal donor tissue. Postgrad Dent. 1996;3:14-21
  27. Tal H. Subgingival acelluar dermal matrix allograft for the treatment of gingival recession : a case report. J Periodontol 1999;70:1118-1124 https://doi.org/10.1902/jop.1999.70.9.1118
  28. Aichelmann-Reidy ME, Yunka RA, Evans GH, Nasr HF, Mayer ET. Clinical evaluation of acellular allograft dermis for the treatment of human gingival recession. J Periodontol 2001;72:998-1005 https://doi.org/10.1902/jop.2001.72.8.998
  29. Tal H. Subgingival acelluar dermal matrix allograft for the treatment of gingival recession : A case report. J Periodontol. 1999;70:1118-1124 https://doi.org/10.1902/jop.1999.70.9.1118
  30. Randall J. Harris Root coverage with a connective tissue with partial thickness double pedicle graft and an acellular dermal matrix graft: A clinical and histological evaluation of a case report. J Periodontol 1998:69:1305-1311 https://doi.org/10.1902/jop.1998.69.11.1305
  31. Cristgau M, Schmalz G, Wenzel A periodontal regeneration of intrabony defects with resorbable and nonresorbable mem branes : 30 month results J. Clin. Periodontol. 1991;18:581-586 https://doi.org/10.1111/j.1600-051X.1991.tb00093.x
  32. Weltman R, Trojo PM, Caffesse R. Assessment of guided tissue regeneration procedures in intrabony defects with bioresorbable and nonresorbable barriers. J Periodontol 1997;72:582-591
  33. Benjamin L. Beckstead, Sheng Pan Esophageal epithelial cell interaction with synthetic and natural scaffolds for tissue engineering. Biomaterials 2005;26:6217-6228 https://doi.org/10.1016/j.biomaterials.2005.04.010
  34. Burke JF, Yannas IV Successful use of a physiologically acceptable artificial skin in the treatment of extensive burn injury. Ann Surg 1981;194:413-428 https://doi.org/10.1097/00000658-198110000-00005
  35. Bell E. Ehrlich HP, Buttle DJ Living tissue formed in vitro and accepted as skin equivalent tissue of full-thickness. Science 1981;211:1052-1054 https://doi.org/10.1126/science.7008197
  36. Sottosanti JS Calcium sulfate:A biodegradable and a biocompatible barrier for guided tissue regeneration. Compend Contin Educ Dent 1992;13:226-228
  37. Anson D. Saving periodontally 'hopeless teeth' using calcium sulfate and demineralized freeze-dried bone allograft. Compend Contin Educ Dent 1998;19:284-298
  38. 장현선.강동완.최용석.박종태. ' 사람치주인대섬유세포의 증식 발판으로서의 acellular dermal matrix의 평가.' '구강생물학회지' 2005;29:115-126