Journal of Periodontal and Implant Science

Korean Academy of Periodontology (대한치주과학회)
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Experimental Study on the Acellular Dermal Matrix Graft for the Root Coverage in Dog

성견에서 ADM(acellular dermal matrix)의 치근피개 효과에 관한 실험적 연구

  • Cho, Min-Young (Department of Implantology, Graduate School of Clinical Dentistry, Ewha Womans University) ;
  • Lee, Seoung-Ho (Department of Periodontology, Graduate School of Clinical Dentistry, Ewha Womans University, Department of Periodontology, School of Medicine, Ewha Womans University) ;
  • Han, Keum-Ah (Department of Periodontology, School of Medicine, Ewha Womans University) ;
  • Lee, Jun-Young (Department of Periodontology, School of Medicine, Ewha Womans University) ;
  • Jeon, Hye-Ran (Department of Implantology, Graduate School of Clinical Dentistry, Ewha Womans University, Department of Periodontology, School of Medicine, Ewha Womans University) ;
  • Kang, Na-Ra (Department of Implantology, Graduate School of Clinical Dentistry, Ewha Womans University) ;
  • Kim, Myung-Rae (Department of Implantology, Graduate School of Clinical Dentistry, Ewha Womans University)
  • 조민영 (이화여자대학교 임상치의학대학원 임플란트학과) ;
  • 이승호 (이화여자대학교 임상치의학대학원 치주과학교실, 이화여자대학교 의과대학/이화의료원 목동병원 치주과) ;
  • 한금아 (이화여자대학교 의과대학/이화의료원 목동병원 치주과) ;
  • 이준영 (이화여자대학교 의과대학/이화의료원 목동병원 치주과) ;
  • 전혜란 (이화여자대학교 임상치의학대학원 임플란트학과, 이화여자대학교 의과대학/이화의료원 목동병원 치주과) ;
  • 강나라 (이화여자대학교 임상치의학대학원 임플란트학과) ;
  • 김명래 (이화여자대학교 임상치의학대학원 임플란트학과)
  • Published : 2006.03.30
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Abstract

결합조직이식을 이용한 치근피개 술식에 많은 관심이 집중되고 있다. 최근에는 acellular dermal matrix가 자가 결합조직 이식편의 대체물로써 소개되었다. 본 실험의 목적은 치근피개를 위해 acellular dermal matrix을 사용시, 그 임상 효과 빚 조직 치유 양상을 평가하고, 이를 자가 결합조직 이삭시의 결과와 비교하기 위함이다. 3마리의 성견에 인위적인 치은 퇴축부 형성을 위해서, 상악 좌우견치의 협측에서 각화치은을 모두 제거하고, 법랑백악경계부로부터 12mm 정도 치조골을 삭제한 후에 판막을 봉합하였다. 그 후 35일을 치유 기간으로 부여하였다. 총 6 부위의 결손부가 실험에 포함되었고, 각각 3 부위씩이 대조군과 실험군으로 분류되었다. 실험군에서는 acellular dermal matrix 이식과 치관측 변위 판막을 시행하였고, 대조군에서는 치은 퇴축부위에 자가 결합조직 이식과 치관측 변위 판막을 시행하였다. 치주낭 깊이, 임상적 부착 수준, 치은 퇴축 높이, 각화조직 높이 등을 인위적 결손부 형성전, 치은 피개술 시행 직전, 피개술 시행후 4주 경과시에 각각 측정하였다. 술후 4주시에, 상악 좌우 견치 부위에서 시편을 얻어 조직학적으로 관찰하고 Wilcoxon signed rank test 와 Mann-Whitney U test으로 통계처리하였다. 임상결과 관찰시, 대조군과 실험군 모두에서, 술전과 비교시 치은 퇴축 감소와 각화조직의 증가, 임상 부착수준의 개선이 나타났다.(p ( 0.05) 평균 치근 피개율은 실험군에서 61.33(5.67%(n=3), 대조군에서 55.67(5.67%(n=3) 이었고, 대조군과 실험군에서 임상결과에서는 통계학적으로 유의성 있는 차이는 없었다.(p ( 0.05). 조직학상으로는, 두 군 모두에서 이식편이 수여부에 잘 융화되어 있었고 비슷한 치유 양상을 보였다. 이상의 실험결과에 의하면, Acellular dermal matrix은 치근피개술 시행시에 결합조직 이식편의 대용품으로 사용할 수 있고 비슷한 피개 결과를 얻을수 있었다.

Keywords

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