DOI QR코드

DOI QR Code

일부 종합병원의 건강검진 수검자들의 한약·양약 복합투여

Combined utilization with herbal products and prescribed drugs: A result from health examinee-based national survey

  • 박종구 (연세대학교 원주의과대학 예방의학교실) ;
  • 최서영 (하나한방병원 하나의학연구소) ;
  • 고광욱 (고신대학교 의과대학 예방의학교실) ;
  • 유준상 (상지대학교 한의과대학 한방내과교실) ;
  • 김태현 (하나한방병원 하나의학연구소) ;
  • 손동국 (연세대학교 원주의과대학 예방의학교실) ;
  • 홍주희 (이화대학교 의과대학 예방의학교실) ;
  • 송성은 (고신대학교 의과대학 예방의학교실) ;
  • 김춘배 (연세대학교 원주의과대학 예방의학교실)
  • Park, Jong-Ku (Department of Preventive Medicine, Yonsei University Wonju College of Medicine) ;
  • Choi, Seo-Young (Hana Medical Research Center, Hana Oriental Hospital) ;
  • Koh, Kwang-Wook (Department of Preventive Medicine, Kosin University College of Medicine) ;
  • Yu, Jun-Sang (Department of Oriental Internal Medicine, Sang Ji University College of Oriental Medicine) ;
  • Kim, Tae-Hun (Hana Medical Research Center, Hana Oriental Hospital) ;
  • Sohn, Dong-Kook (Department of Preventive Medicine, Yonsei University Wonju College of Medicine) ;
  • Hong, Ju-Hee (Department of Preventive Medicine, Ewha Woman University College of Medicine) ;
  • Song, Sung-Eun (Department of Preventive Medicine, Kosin University College of Medicine) ;
  • Kim, Chun-Bae (Department of Preventive Medicine, Yonsei University Wonju College of Medicine)
  • 발행 : 2006.03.01

초록

Recently, there has been prevailing of the combined utilization (CU) with herbs and prescribed drugs in medical therapies in the world. But the information about frequency, efficacy and safety of this CU has not well known in Korea, yet. This study aimed to identify the status of CU by Koreans, and to inquire which side effects of CU represent to those people. A self-completed questionnaire survey was performed through each health examination center in twenty general hospitals and one oriental hospital. Of the initial 2,100 health examinees, 1,851 were participated in this survey, resulting in a response rate of 88.1%. The proportion of CD was 26.3%. The most commonly mentioned reason of CD was 'to promote general health and well-being' (17l persons, 35.5%). The main route of taking CD was self-purchase at drugstore or at herbs market, followed by the prescription of (oriental)physicians. 33.0% (151 persons) of those who took the CD rated it as effective. 93 respondents (19.8%) were experienced several adverse effects including nausea, fatigue, and dizziness. The growing simultaneous use of herbal products and pharmaceutical drugs by Korean consumers may be continuously increased the risk of herb-drug interactions. The medical professionals should be provided with comprehensive and up-to-date information about potential benefits and risks of herbs and prescribed drugs. In the future studies it may be recommended to deal common cold, health promotion, indigestion, headache, and hypertension for the effect and safety of the CD by well-organized prospective study design.

키워드

참고문헌

  1. 김종석. 약물상호작용(현대약과 한약). 유성출판사. 1996
  2. 남기덕, 이태원, 노정현, 양문호, 조병수, 홍성표 등. Chinese Herbs Nephropathy 1예. 대한신장학회지 2000;19(4):751-755
  3. 박종구, 김춘배, 최서영, 김달래, 전세일, 이선동 등. 보완.대체의학에 대한 시론. 보건행정학회지 2000;10(1):1-30
  4. 박종구, 이종인, 김장현, 방동식. 양한방의 상호보완 발전방안 연구. 보건복지부 보건의료기술연구개발사업(정책과제) 최종보고서. 2000
  5. 보건복지부. 보도자료 2004년 1월 16일자
  6. 신현진, 홍정희, 고현철, 신인수, 최호순, 김태화 등. 1형과 2형 당뇨모델 흰쥐에서 chromium picolinate의 당내성과 인슐린 감수성에 대한 영향. 음용약물학회지 2001;9:277 -281
  7. 서홍관. '한.양방 의료일원화' 이종찬 엮음. 한국의료대논쟁. 소나무 2000. 286-290
  8. 이원철, 김성완, 이문성, 김장현, 김춘배. 주요 난치성 질환에 대한 한양방 협진의 임상효과검증 및 한양방 협진 의료기관의 운영모델 개발. 보건복지부 보건의료기술연구개발사업(정책 과제) 최종보고서. 2002
  9. 이용일, 변정환, 남철현. 도시지역주민의 한약복용실태와 이에 영향을 미치는 요인분석. 대한보건협회학술지 1991;17(1):32-49
  10. 이지전, 오희철, 이상욱. 사망전 노인의 전체 보건의료비용에서 보완대체의료 비용과 비용분율에 관한 연구. 예방의학회지 2004;37:141-149
  11. 조선일보. 2000.10.18일자
  12. 조재국, 이상영, 신숙식, 이우백, 김민순. 양.한방 협진실태와 정책방향. 한국보건사회연구원정책보고서 1999. 99-14
  13. 최기환, 김순선, 박윤주, 안미령, 서수정, 신윤용 등. 천연물이 간대사에 미치는 영향에 관한 연구. 식품의약품안전청연보 1997;1:549-566
  14. Bailey CJ. Drugs inducing hypoglycemia. Pharmacol Ther 1989;42(3):361-84 https://doi.org/10.1016/0163-7258(89)90031-4
  15. Bandolier's Web site. http://www.jr2.ox.ac.uk/bandolier/band7l/b71_7.html
  16. Bent S, Ko R. Commonly used herbal medicines in the United States: a review. Am J Med 2004; 116(7) :478-485 https://doi.org/10.1016/j.amjmed.2003.10.036
  17. Brown AC. Life-threatening herbs causing liver toxicity, renal toxicity, cardiotoxicity, cancer and death (abstract 489.29). Experimental Biology 2002 meeting. April 22 2002. New Orleans
  18. Burstein HJ, Gelber S, Guadagnoli E, Weeks JC. Use of alternative medicine by women with early-stage breast cancer. N Engl J Med 1999;340(22):1733-1739 https://doi.org/10.1056/NEJM199906033402206
  19. Canter PH, Ernst E. Herbal supplement use by persons aged over 50 years in Britain: frequently used herbs, concomitant use of herbs, nutritional supplements and prescription drugs, rate of informing doctors and potential for negative interactions. Drugs Aging 2004;21(9):597-605 https://doi.org/10.2165/00002512-200421090-00004
  20. Cheng KF, Leung KS, Leung PC. Interactions between modern and Chinese medicinal drugs: A general review. Am J Chin Med 2003;31(2): 163-169 https://doi.org/10.1142/S0192415X0300093X
  21. Eisenberg DM, Davis RB, Ettner SL, et al. Trends in alternative medicine use in the United States, 1990-1997. JAMA 1998;280:1569-1575 https://doi.org/10.1001/jama.280.23.1990
  22. Ernst E. Risks of herbal medicinal products. Pharmacoepidemiol Drug Saf 2004;13(1):767-771 https://doi.org/10.1002/pds.1014
  23. Fisher P, Ward A. Complementary medicine in Europe. BMJ 1994;309:107-111 https://doi.org/10.1136/bmj.309.6947.107
  24. Fugh-Berman A, Ernst E. Herb-drug interactions: review and assessment of report reliability. Br J Clin Pharmacol 2001;52:587-595 https://doi.org/10.1046/j.0306-5251.2001.01469.x
  25. German Commission E monographs. Available from: ULR: http://www. herbalgram.org/browse.php/comission_e
  26. Harnack LJ, Rydell SA, Stang J. Prevalence of use herbal products by adults in the Minneapolis/St. Paul, Minn, metropolitan area. Mayo Clin Proc 2001;76:688-694
  27. Izzo AA, Ernst E. Interactions between herbal medicines and prescribed drugs: A systemic review. Drugs 2001; 61(15): 2163-2175 https://doi.org/10.2165/00003495-200161150-00002
  28. Izzo AA. Herb-drug interactions: an overview of the clinical evidence. Fundam Clin Pharmacol 2005;19(1):1-16 https://doi.org/10.1111/j.1472-8206.2004.00301.x
  29. Klepser TB, Klepser ME. Unsafe and potentially unsafe herbal therapies. Am J Health-System Pharmacists 1999;56:125-138
  30. MacLennan AH, Wilson DH, Taylor AW. Prevalence and cost of alternative medicine in Australia. Lancet 1996;347:569-573 https://doi.org/10.1016/S0140-6736(96)91271-4
  31. Markowits JS. Drug Metabolism and Disposition. 2003;31:519-522 https://doi.org/10.1124/dmd.31.5.519
  32. Mills E, Montori VM, Wu P, Gallicano K, Clarke M, Guyatt G. Interaction of St John's wort with conventional drugs: systematic review of clinical trials. BMJ 2004;329(7456): 27-30 https://doi.org/10.1136/bmj.329.7456.27
  33. NCCAM Consumer Advisory on Ephedra (2003). Available from ULR : http://nccam.nci.nih.gov/health/alerts/ephedra/consumeradvisory.htm
  34. Rafferty AP, McGee HB, Miller CE, Reyes M. Prevalence of complementary and alternative medicine use: state-specific estimates from the 2001 Behavioral Risk Factor Surveillance System. Am J Public Health 2002;92:1598-1600 https://doi.org/10.2105/AJPH.92.10.1598
  35. Science News, (2002). Available from ULR : http://www.sciencenews.org/20020504/food.asp
  36. Strader DB, Bacon BR, Lindsay KL, La Brecque DR, Morgan T, Wright EC, et al. Use of complimentary and alternative medicine in patients with liver disease. Am J Gastroenterol 2002;97(9):2391-2397 https://doi.org/10.1111/j.1572-0241.2002.05993.x