Archives of Pharmacal Research

  • 제29권4호
  • /
  • Pages.276-281
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  • 2006
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  • 0253-6269(pISSN)
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  • 1976-3786(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

Synthesis and Cytotoxic Activities of 8-Alkyl or 8-Aryl-8,9-dihydro-7H-isoindolo[5,6-g]quinoxaline-7,9-diones

  • Jung Jae-Kyung (College of Pharmacy, Chungbuk National University) ;
  • Jung Eun-Kyung (College of Pharmacy, Chungbuk National University) ;
  • Kwon Nam-Goong (College of Pharmacy, Chungbuk National University) ;
  • Cho Jung-Sook (College of Medicine, Dongguk University) ;
  • Kim Hwan-Mook (Korea Research Institute of Bioscience and Biotechnology) ;
  • Park Sung-Gyu (Korea Research Institute of Bioscience and Biotechnology) ;
  • Yoo Yeong-Ah (Korea Research Institute of Bioscience and Biotechnology) ;
  • Kwon Joo-Hee (Korea Research Institute of Bioscience and Biotechnology) ;
  • Lee Hee-Soon (College of Pharmacy, Chungbuk National University)
  • 발행 : 2006.04.01
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초록

A series of 8-alkyl-and 8-aryl-8,9-dihydro-7H-isoindolo[5,6-g]quinoxaline-7,9-diones were synthesized using sultine chemistry as a key step in good yield. These compounds were evaluated for their in vitro cytotoxicity against six human cancer cell lines (HCT15, SK-OV-3, A549, SNB19, MCF7 and MCF7/ADR).

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참고문헌

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