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Effects of Cheonggukjang Added Phellinus linteus on Lipid Metabolism in Hyperlipidemic Rats

고지혈증 흰쥐에 청국장 및 상황버섯 청국장이 지질대사에 미치는 효과

  • 고진복 (신라대학교 생명과학과)
  • Published : 2006.04.01

Abstract

The effects of cheonggukjang (traditional fermented soybean food, CK) and cheonggukjang added Phellinus linteus (CKP) on lipid metabolism were investigated in adult male rats. Twenty weeks old Sprague-Dawley rats were fed a purified hyperlipidemic diet (control diet: 0.5% cholesterol, 10% fat, 18% casein) for 4 weeks. The rats were randomly assigned to each treatment group control, two kinds of CK or CKP (powders of CK or CKP as dietary protein sources) After 5 weeks of CK or CKP diets consumption, the body weights, the hepatic and epididymal fat pad weights of the CK or CKP diets groups were significantly decreased than those of the control group. The liver cholesterol and triglyceride levels were significantly lower in both the CK and CKP diets groups than those in the control group. The concentrations in serum triglyceride, total cholesterol, LDL-cholesterol, and atherogenic index ratios were significantly decreased in the CK and CKP diets groups compared with those in the control group. The HDL-cholesterol/total-cholesterol ratios were significantly increased in the CK and CKP diets groups compared with those in the control group. Fecal cholesterol and triglyceride excretion of the CK and CKP diets groups were significantly increased than those of the control group. These results showed that both the feeding of cheonggukjang and cheonggukjang added Pheilinus linteus decreased the triglyceride, total cholesterol and LDL-cholesterol in serum as well as the triglyceride and cholesterol in liver, and increased the HDL-cholesterol/total-cholesterol ratio in serum of the rats.

청국장 분말이 고지방식이를 섭취한 흰쥐의 지질대사에 미치는 영향을 조사하고자, 성숙한(생후 20주령) 숫쥐를 4주간 고지방식이(0.5% 콜레스테롤, 10% 지방)로 고지혈증을 유도한 후 대조군(고지방식이), 청국장군(고지방식이에 단백질원으로 청국장 분말을 첨가한 식이) 및 상황버섯 청국장군(고지방식이에 단백질원으로 상황버섯 청국장 분말을 첨가한 식이 ) 등 3군으로 나누어 5주간 사육한 결과는 다음과 같다. 실험동물의 체중은 대조군이 41.8 g증가함에 비하여 청국장군 및 상황버섯 청국장군은 각 -3.7 g 및 -0.8 g으로 유의하게 감소되었고, 식이섭취량 및 식이효율은 대조군에 비하여 청국장군들이 유의하게 감소되었다. 간과 부고환지방의 무게 및 간조직의 콜레스테롤과 중성지질 농도는 대조군에 비하여 청국장군 및 상황버섯 청국장군이 유의하게 감소시키는 효과가 나타났다. 혈청의 중성지질, 총 콜레스테롤, LDL-콜레스테롤, VLDL-콜레스테롤 농도 및 동맥경화지수는 대조군에 비해 청국장군 및 상황버섯 청국장군이 유의하게 감소되었다. 총 콜레스테롤에 대한 HDL-콜레스테롤의 비율은 대조군에 비해 청국장군들이 유의하게 증가되었다. 변의 무게, 총 지질, 중성지질 및 콜레스테롤 배설량은 청국장군들이 대조군보다 유의하게 증가된 것으로 나타났다. 이상의 결과로 보아 고지방식이에 청국장 및 상황버섯청국장 분말을 첨가 섭취시 혈청과 간조직의 중성지질, 총콜레스테롤과 LDL-콜레스테롤 농도 및 동맥 경화지수를 낮추고, 총 콜레스테롤에 대한 HDL-콜레스테롤의 비율을 증가시키는 지질대사의 개선 효과가 나타났다.

Keywords

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