Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Effect of High Fat Diet Containing Hangbisan on the Body Weight and Blood Lipid Composition in the Rats

항비산을 함유한 고지방식이가 흰쥐의 체중증가 및 혈중지질 함량에 미치는 영향

  • Chae, Myoung-Hee (Dept. of Food and Nutrition and Human Ecology Research institute, Chonnam National University) ;
  • No, Jin-Gu (Baek-du Oriental Medicine Center) ;
  • Jhon, Deok-Young (Dept. of Food and Nutrition and Human Ecology Research institute, Chonnam National University)
  • Published : 2006.04.01
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Abstract

Among the oriental medicine compounds, sulfur is known as a heat-generation material in a human body. Heat-generation reaction results in the consumption of energy source. Some oriental herbs are used to treat obesity and blood lipid composition. Therefore, we hypothesized that a sulfur containing oriental medicine compound, called as Hangbisan, could help weight loss of experimental rats. This study was designed to observe the change of weight of Sprague-Dawley (SD) rats that had been fed with high-fat diet containing 10% cellulose or Hangbisan for 9 weeks. Hangbisan affected the weight loss of rats as reducing the level of plasma cholesterol and triglyceride and increasing the level of HDL-cholesterol. Thus, this study revealed Hangbisan have an anti-obesity effect and a potential role for anti-obesity agent in the application of oriental medicine compounds.

한약에서 사용하는 유황은 인체에서 열을 발생하는 물질로서 에너지 소모를 일으킨다. 청피,시호, 지실 등의 한약재는 이기(理氣), 조습건비(燥濕健脾), 이수삼습(利水渗濕), 활혈거어 (活血祛瘀)의 효능이 있어서 비만을 치료하는 약물로 한의학에서 이용되고 있다. 본 연구에서는 유황을 함유하는 항비산이 실험동물의 체중을 감소시키는데 도움이 될 것으로 가정하고 항비산을 흰쥐에 투여한 후 체중감량 및 혈액지질조성에 미치는 효과를 조사하였다. 4주령의 SD계 흰쥐에 9주 동안 10% 항비산이 함유된 고지방식이와 대조군으로서 10% cellulose가 함유된 식이를 공급하였다. 유황이 주로 함유된 한약재인 항비산을 섭취하는 동안 흰쥐의 건강상태는 양호하였다. 항비산은 흰쥐를 생육하는 동안 고지방식이와 병행 공급 시 10% cellulose가 갖는 정도의 체중감소효과를 나타냈다. 혈중 총 콜레스테롤과 중성 지방은 감소하고 HDL-콜레스테롤은 증가하여 혈중지질 조성을 개선시키는 작용이 있었다. 또한 흰쥐의 간 기능에는 독성을 나타내지 않았다. 따라서 임상연구를 포함한 더 많은 연구가 필요하지만 이상의 결과로 본 실험에서 사용한 항비산은 혈액지방 조성을 개선하여 비만인의 체중감량에 이용될 수 있을 것으로 사료된다.

Keywords

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