Preventive Nutrition and Food Science

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
권호 표지
DOI QR코드

DOI QR Code

Inhibitory Effects of Actinidia chinensis and Zizyphus jujube on Histamine Release from Rat Peritoneal Mast Cells

  • Yang, Su-Ok (Department of Food and Nutrition, Research Institute of Human Ecology, Seoul National University) ;
  • Ji, Geun-Eog (Department of Food and Nutrition, Research Institute of Human Ecology, Seoul National University)
  • Published : 2006.06.01
Download PDF
⟨ Previous Next ⟩

Abstract

Methanol extracts (80%, $10{\mu}g/mL$) of Actinidia chinensis (AC) and Zizyphus jujube(ZJ) inhibited histamine release from rat peritoneal mast cells (RPMCs) induced by compound 48/80. Evaluation of AC and ZJ solvent fractions (chloroform, ethylacetate, butanol and water) revealed that the butanol fraction of AC at $5{\mu}g/mL$ and water fraction of ZJ at $1{\mu}g/mL$ exhibited the highest anti-allergic effects. Combination of the butanol fraction of AC and water fraction of ZJ when combined showed higher inhibition of histamine release than either alone. The levels of cAMP in RPMCs treated with AC and ZJ were significantly increased compared to the compound 48/80 treated control. Our findings suggest that the extracts from AC and ZJ may alleviate immediate hypersensitivity reactions through the increase of cAMP in the mast cells.

Keywords

References

  1. Kay AB. 2001. Allergy and allergic diseases. N Engl J Med 344: 1-6
  2. Choi YO. 2002. Anti-allergic effects of Petasites japonicum. Kor J Food Nutr 15: 382-385
  3. Kamei C, Akagi M, Mio M, Kitazumi K, Izushi K, Masaki S, Tasaka K. 1992. Antiallergic effect of epinastine (WAL 801 CL) on immediate hypersensitivity reactions: (I). Elucidation of the mechanism for histamine release inhibition. Immunopharmacol Immunotoxicol 14: 191-205 https://doi.org/10.3109/08923979209009219
  4. Kamei C, Mio M, Kitazumi K, Tsujimoto S, Yoshida T, Adachi Y, Tasaka K. 1992. Antiallergic effect of epinastine (WAL 801 CL) on immediate hypersensitivity reactions: (II). Antagonistic effect of epinastine on chemical mediators, mainly antihistaminic and anti-PAF effects. Immunopharmacol Immunotoxicol 14: 207-218 https://doi.org/10.3109/08923979209009220
  5. Kazuhisa M, Tomoaki S, Hideki S, Yuki T, Katsuyu S, Yutaka G, Ryozo O. 1998. Inhibition of neuronal dopamine uptake by some antiallergic drugs. Eur J Pharmacol 350: 165-169 https://doi.org/10.1016/S0014-2999(98)00253-2
  6. Yang SO. 2006. Inhibitory effect of natural food extracts on histamine release from rat peritoneal mast cells. MS thesis. Seoul National University
  7. Chan S, Gong J, Liu F, Mohammed U. 2000. Naturally occurring polyphenolic antioxidants modulate IgE-mediated mast cell activation. Immunology 100: 471-480 https://doi.org/10.1046/j.1365-2567.2000.00045.x
  8. Mousli M, Bronner C, Bockaert J, Rouot B, Landry Y. 1990. Interaction of substance P, compound 48/80 and masto-paran with the ${\alpha}$-subunit C-terminus of G protein. Immunol Lett 25: 355-357 https://doi.org/10.1016/0165-2478(90)90207-7
  9. Tasaka K, Mio M, Okamoto M. 1986. Intracellular calcium release induced by histamine releasers and its inhibition by some antiallergic drugs. Ann Allergy 56: 464-469
  10. Makino H, Saijo T, Ashida Y, Kuriki H, Maki Y. 1987. Mechanism of action of an antiallergic agent, Amlexanox (AA-673), in inhibiting histamine release from mast cells. Int Arch Allergy Appl Immunol 82: 66-71 https://doi.org/10.1159/000234292