Asian-Australasian Journal of Animal Sciences

  • 제19권6호
  • /
  • Pages.763-768
  • /
  • 2006
  • /
  • 1011-2367(pISSN)
  • /
  • 1976-5517(eISSN)
아세아태평양축산학회 (Asian Australasian Association of Animal Production Societies)
권호 표지
DOI QR코드

DOI QR Code

Association of MC4R Gene Polymorphisms with Growth and Body Composition Traits in Chicken

  • Li, Chun-Yu (College of Animal Science and Technology, Northeast Agricultural University) ;
  • Li, Hui (College of Animal Science and Technology, Northeast Agricultural University)
  • 투고 : 2005.08.18
  • 심사 : 2006.01.09
  • 발행 : 2006.06.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Genetic and pharmacological studies in mice have demonstrated a complementary role for the melanocortin 4 receptor (MC4R) in the control of food intake, energy balance and body weight. This study was designed to investigate the associations of a MC4R gene polymorphism on chicken growth and body composition traits in broiler lines divergently selected for abdominal fat. A SNP (G54C) was found in CDS region of chicken MC4R gene. The analysis of the least squares and variance revealed a significant association between the G54C SNP and BW, CW and SL at 7 wk of age, and there were significant differences in different genotypes (p<0.05). The results from protein secondary structure prediction and tertiary structure prediction showed that it appeared a helix in $13^{th}$ amino acid and two strands at $14^{th}$ and $15^{th}$ amino acid in mutant protein, respectively. It maybe induce the change of the activity or function of MC4R gene in poultry.

키워드

참고문헌

  1. Baskin, D. G., T. M. Hahn and M. W. Schwartz. 1999. Leptin sensitive neurons in the hypothalamus. Horm. Metab. Res. 31:345-350 https://doi.org/10.1055/s-2007-978751
  2. Boldman, K. and D. V. Vleck. 2002. MTDFREML manual, United States Department of Agriculture, USA
  3. Butler, A. A., R. A. Kesterson, K. Khong, M. J. Cullen, M. A. Pelleymounter, J. Dekoning, M. Baetscher and R. D. Cone. 2000. A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse. Endocri. 141(9):3518-3521 https://doi.org/10.1210/en.141.9.3518
  4. Chung, E. R. and W. T. Kim. 2005. Association of SNP Marker in IGF-I and MYF5 candidate genes with growth graits in korean cattle. Asian-Aust. J. Anim. Sci. 18(8):1061-1065 https://doi.org/10.5713/ajas.2005.1061
  5. Cone, R. D. 1999. The central melanocortin system and energy homeostasis. Trends Endocrinol. Metab. 10(6):211-215 https://doi.org/10.1016/S1043-2760(99)00153-8
  6. Deeb, N. and S. J. Lamont. 2002. Genetic architecture of growth and body composition in unique chicken population. J. Hered. 93:107-118 https://doi.org/10.1093/jhered/93.2.107
  7. Dumont, L. M., C. S. Wu, M. A. Tatnell, J. Cornish, K. G. Mountjoy. 2005. Evidence for direct actions of melanocortin peptides on bone metabolism. Peptides. 26:1929-1935 https://doi.org/10.1016/j.peptides.2004.12.034
  8. Hagan, M. M., P. A. Rushing, M. W. Schwartz, K. A. Yagaloff, P. Brun, S. C. Wodds and R. J. Seely. 1999. Role of the CNS melanocortin system in the response to overfeeding. J. Neurosci. 19(6):2362-2367 https://doi.org/10.1523/JNEUROSCI.19-06-02362.1999
  9. Hinney, A., A. Schmidt, K. Nottebom, O. Heibult, W. Beckfried, M. Fichter, H. Remschmidt and J. Hebebrand. 1999. Several mutations in the melancortin-4 receptor gene including a nonsense and a frame shift mutaion associated with dominantly inherited obesity in humans. J. Clin. Endocrionl. Metab. 84(4):1483-1486 https://doi.org/10.1210/jc.84.4.1483
  10. Ho, G. and R. G. Mackenzie. 1999. Functional characterization of mutations in melanocortin-4 receptor associated with human obesity. J. Biol. Chem. 274(50):35816-35822 https://doi.org/10.1074/jbc.274.50.35816
  11. Huszar, D., C. A. Lynch, V. Fairchild-Huntress, J. H. Dunmore, Q. Fang, L. R. Berkemeier, W. Gu, R. A. Kesterson, B. A. Boston, R. D. Cone, F. J. Smith, L. A. Campfield, P. Burn and F. Lee. 1997. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell. 88(1):131-141 https://doi.org/10.1016/S0092-8674(00)81865-6
  12. Hwa, J. J., L. Ghibaudi, J. Gao and E. M. Parker. 2001. Central melanocortin system modulates energy intake and expenditure of obese and lean Zucker rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 281:444-451 https://doi.org/10.1152/ajpregu.2001.281.2.R444
  13. Ikeobi, C. O. N., J. A. Woolliams, D. R. Morrice, A. Law, D. Windsor, D. W. Burt and P. M. Hocking. 2002. Quantitative trait loci affecting fatness in the chicken. Anim. Genet. 33:428- 435 https://doi.org/10.1046/j.1365-2052.2002.00911.x
  14. Jiang, Y. L., N. Li, X. Z. Fan, L. R. Xiao, R. L. Xiang, X. X. Hu, L. X. Du and C. X. Wu. 2002b. Associations of $T^{0}CA$ mutation in the promoter region of myostatin gene with birth weight in Yorkshire pigs. Asian-Aust. J. Anim. Sci. 15(11):1543-1545 https://doi.org/10.5713/ajas.2002.1543
  15. Julian, R. J. 1998. Rapid growth problems: ascites and skeletal deformities in broilers. Poult. Sci. 77:1773-1780 https://doi.org/10.1093/ps/77.12.1773
  16. Kask, A., L. Rago, J. Wikberg and H. B. Schioth. 1998. Evidence for involvement of the melanocortin 4 receptor in the effects of leptin on food intake and body weight. Eur. J. Pharmacol. 360 (1):15-19 https://doi.org/10.1016/S0014-2999(98)00699-2
  17. Kim, K. S., N. Larsen, T. Short, G. Plastow and M. F. Rothschild. 2000. A missense variant of the porcine melanocortin-4 receptor (MC4R) gene is associated with fatness, growth and feed intake traits. Mamm genome. 11:131-135 https://doi.org/10.1007/s003350010025
  18. Kim, T. H., B. H. Choi, H. K. Lee, H. S. Park, H. Y. Lee, D. H. Yoon, J. W. Lee, G. J. Jeon, I. C. Cheong, S. J. Oh and J. Y. Han. 2005. Identification of quantitative traits loci (QTL) affecting growth traits in pigs. Asian-Aust. J. Anim. Sci. 18(11):1524-1528 https://doi.org/10.5713/ajas.2005.1524
  19. King, P. J., P. S. Widdowson, H. Doods and G. Williams. 2000. Regulation of neuropeptide Y release from hypothalamic slices by melanocortin-4 agonists and leptin. Peptides. 21(1):45-48 https://doi.org/10.1016/S0196-9781(99)00168-0
  20. Koegler, F. H., K. L.Grove, A. Schiffmacher, M. S. Smith and J. L. Cameron. 2001. Central melanocortin receptors mediate changes in food intake in the Rhesus Macaque. Endocri. 6(142):2586-2592
  21. Li, H., N. Deeb, H. Zhou, A. D. Mitchell, C. M. Ashwell and S. J. Lamont. 2003. Chicken quantitative trait loci for growth and body composition associated with transforming growth factor- ${\beta}$ genes. Poult. Sci. 82:347-356 https://doi.org/10.1093/ps/82.3.347
  22. MacNeil, D. J., A. D. Howard, X. Guan, T. M. Fong, R. P. Nargund, M. A. Bednarek, M. T. Goulet, D. H. Weinberg, A. M. Strack, D. J. Marsh, H. Y. Chen, C. P. Shen, A. S. Chen, C. I. Rosenblum, T. MacNeil, M. Tota, E. D. MacIntyre and L. H. Van der Ploeg. 2002. The role of melanocortins in body weight regulation: opportunities for the treatment of obesity. Eur. J. Pharmacol. 450:93-109 https://doi.org/10.1016/S0014-2999(02)01989-1
  23. Meng, H., J. G. Zhao, Z. H. Li and H. Li. 2005. Single nucleotide polymorphism on peroxisome proliferators- activated receptor genes associated with fatness traits in chicken. Asian-Aust. J. Anim. Sci. 18(9):1221-1225 https://doi.org/10.5713/ajas.2005.1221
  24. Mizuno, T. M. and C. V. Mobbs. 1999. Hypothalamic agoutirelated protein messenger ribonucleic acid is inhibited by leptin and stimulated by fasting. Endocri. 140:814-817 https://doi.org/10.1210/en.140.2.814
  25. Robert, B. 2005. The complex interplay between fat and bone. Cellscience Reviews. 4:71-77
  26. Roger, A. H. and W. H. Gispen. 1997. Brain melanocortin receptors: from cloning to function. Reptides. 8:1279-1287
  27. Rothschild, M. F. and M. Soller. 1997. Candidate gene analysis to detect genes controlling traits of economic importance in domestic livestock. Probe. 8:13-20
  28. Schwartz, M. W., R. J. Seeley, L. A. Campfield, P. Burn and D. G. Baskin. 1996. Identification of targets of leptin action in rat hypothalamus. J. Clin. Invest. 98:1101-1106 https://doi.org/10.1172/JCI118891
  29. Schwartz, M. W., S. C. Woods, D. J. Porte, R. J. Seeley and D. G. Baskin. 2000. Central nervous system control of food intake. Nat. 404:661-671 https://doi.org/10.1038/35007534
  30. Steppan, C. M., D. T. Crawford, K. L. Chidsey-Frink, H. Ke and A. G. Swick. 2000. Leptin is a potent stimulator of bone growth in ob/ob mice. Regul Pept. 92:73-78 https://doi.org/10.1016/S0167-0115(00)00152-X
  31. Strader, A. D., H. B. SchiÖth and J. D. Buntin. 2003. The role of the melanocortin system and the melanocortin-4 receptor in ring dove (Streptopelia risoria) feeding behavior. Brain Res. 960:112-121 https://doi.org/10.1016/S0006-8993(02)03799-X
  32. Takeuchi, S. and S. Takahashi. 1999. A possible involvement of melanocortin 3 receptor in the regulation of adrenal gland function in the chicken. Biochim. Biophys. Acta. 1448(3):512- 518 https://doi.org/10.1016/S0167-4889(98)00165-7
  33. Vaisse, C., K. Clement, E. Durand, S. Hercberg, B. Guy-Grand and P. Froguel. 2000. Melanocortin-4 receptor mutations are a frequent and heterogeneous cars of morbid obesity. J. Clin. Inverst. 106(2):253-262 https://doi.org/10.1172/JCI9238
  34. Vaisse, C., K. Clement, B. Guy-Grand and P. Froguel. 1998. A frame shift mutation in human MC4R is associated with a dominant form of obesity. Nat Genet. 20(2):113-114 https://doi.org/10.1038/2407
  35. Vergoni, V. A. and A. Bertolini. 2000. Role of melanocortins in the central control of feeding. Eur. J. Pharmacol. 405:25-32 https://doi.org/10.1016/S0014-2999(00)00538-0
  36. Xu, D. Q., Y. Z. Xiong, M. Liu, J. Lan, X. F. Ling, C. Y. Deng and S. W. Jiang. 2005. Association analyses with carcass traits in the porcine KIAA1717 and HUMMLC2B genes. Asian-Aust. J. Anim. Sci. 18(11):1519-1541 https://doi.org/10.5713/ajas.2005.1519
  37. Yang, Y. K., D. A. Thompson, C. J. Dickinson, J. Wiken, G. S. Barsh, S. B. Kent and I. Gantz. 1999. Characterization of agouti-related protein binding to melanocortin receptors. Mol. Endocrinol. 13:148-155 https://doi.org/10.1210/me.13.1.148
  38. Zhang, B. Z., M. G. Lei, C. Y. Deng, Y. H. Xiong, B. Zuo and F. E. Li. 2005. Association between PCR-RFLP polymorphism of the fifth intron in lipoprotein lipase gene and productive traits in pig resource family. Asian-Aust. J. Anim. Sci. 18(4):458- 462 https://doi.org/10.5713/ajas.2005.458

피인용 문헌

  1. vol.2007, pp.124, 2007, https://doi.org/10.5983/nl2001jsce.2007.124_19
  2. Association of single-nucleotide polymorphism of melanocortin gene with feed intake in rabbit (Oryctolagus cuniculus) pp.09312439, 2018, https://doi.org/10.1111/jpn.12788
  3. Variation in the Promoter Region of the MC4R Gene Elucidates the Association of Body Measurement Traits in Hu Sheep vol.20, pp.2, 2019, https://doi.org/10.3390/ijms20020240
  4. Association between Polymorphisms of Lipoprotein Lipase Gene and Chicken Fat Deposition vol.19, pp.10, 2006, https://doi.org/10.5713/ajas.2006.1409
  5. Identification of Single Nucleotide Polymorphism of H-FABP Gene and Its Association with Fatness Traits in Chickens vol.20, pp.12, 2006, https://doi.org/10.5713/ajas.2007.1812
  6. A Missense Mutation in the Rabbit Melanocortin 4 Receptor (MC4R) Gene is Associated with Finisching Weight in a Meat Rabbit Line vol.24, pp.4, 2006, https://doi.org/10.1080/10495398.2013.781034