Cutaneous melanocytic tumor in a slaughtered pig

도축돈에서 발생한 피부 멜라닌 세포성 종양

  • Yang, Hyoung-Seok (Department of Veterinary Medicine, Cheju National University) ;
  • Kang, Sang-Chul (Department of Veterinary Medicine, Cheju National University) ;
  • Bae, Jong-Hee (Department of Veterinary Medicine, Cheju National University) ;
  • Kim, Jae-Hoon (Department of Veterinary Medicine, Cheju National University)
  • 양형석 (제주대학교 농업생명과학대학 수의학과) ;
  • 강상철 (제주대학교 농업생명과학대학 수의학과) ;
  • 배종희 (제주대학교 농업생명과학대학 수의학과) ;
  • 김재훈 (제주대학교 농업생명과학대학 수의학과)
  • Accepted : 2006.09.19
  • Published : 2006.09.30

Abstract

A 7-month-old brown pig with a discoid and pedunculate mass measuring $14.0{\times}12.5{\times}2.5cm$ on the skin of the right shoulder was noted at the slaughter house in Jeju. The surface of mass approximately $7{\times}4cm$ was interfaced with skin. The color of mass with firm consistency was mainly black and partially white on cut surface. Histopathologically, numerous unencapsulated endocrine-like cellular nodules of epithelioid cell type with abundant intracytoplasmic black pigment, melanin, were occupied in dermis and subcutis. Most of nodules in deep dermis were surrounded by lightly pigmented spindle cells and loose fibrous tissues. Mitotic figures were infrequently observed. The overlying epidermis was hyperplastic due to the down-growth of rete peg. Based on the gross and histopathologic findings, this case was diagnosed as cutaneous melanoma. In our best knowledge, this is the first case of swine cutaneous melanoma in Korea.

Keywords

References

  1. 강문일, 정운익, 진영화, 권영방, 김공식. 한우와 Brahman 교잡우의 악성 melanoma 발생보고. 농시논문집 1990, 2, 23-31
  2. 강부현, 손화영, 하창수, 김대용. Sprague-Dawley 랫드의 안구에 자연발생한 amelanotic melanoma. 대한수의학회지 1995, 35, 375-381
  3. 양승주, 김영길, 현재석, 문윤희, 정인철. 제주도에서 사육된 개량 흑돼지와 비육돈 등심의 아미노산 함량 및 육질 특성. 한국축산식품학회지 2005, 25, 7-12
  4. 최염순, 박범영, 이종문, 이성기. 재래흑돼지와 개량종 돼지의 도체 및 육질 특성 비교. 한국축산식품학회지 2005, 25, 322-327
  5. 한규보, 조익현, 김현수, 김휘율. 개의 발가락에 발생한 전이성 악성흑색종. 대한수의학회지 2001, 41, 227-231
  6. Amoss MS Jr, Ronan SG, Beattie CW. Growth of Sinclair swine melanoma as a function of age, histopathological staging, and gonadal status. Cancer Res 1988, 48, 1708-1711
  7. Bundza A, Feltmate TE. Melanocytic Cutaneous Lesions and Melanotic Regional Lymph Nodes in Slaughter Swine. Can J Vet Res 1990, 54, 301-304
  8. Caylor HD, Schlotthauer CF. Melanoepithelioma of swine. Arch Pathol Lab Med 1926, 2, 343-351
  9. Case MT. Malignant melanoma in a pig. J Am Vet Med Assoc 1964, 144, 254-256
  10. Fisher LF, Olander HJ. Spontaneous neoplasms of pigs. A study of 31 cases. J Comp Pathol 1978, 88, 505-517 https://doi.org/10.1016/0021-9975(78)90004-X
  11. Goldschmidt MH, Dunstan RW, Stannard AA, von Tscharner C, Walder EJ, Yager JA. Histological classification of epithelial and melanocytic tumors of the skin of domestic Animals. 2nd series. Vol. III. pp. 38-40, Armed Forces Institute of Pathology, Washington, D.C, 1998
  12. Goldschmidt MH, Shofer FS. Skin tumors of the Dog and Cat. pp. 131-141, Butterworth Heinemann, Oxford, 1998
  13. Gross TL, Ihrke PJ, Walder EJ. Veterinary Dermatology: A macroscopic and microscopic evaluation of canine and feline skin disease. pp. 451-459, Mosby Yearbook, St. Louis, 1992
  14. Hook RR Jr, Berkelhammer J, Oxenhandler RW. Melanoma: Sinclair swine melanoma. Am J Pathol 1982, 108, 130-133
  15. Manning PJ, Millikan LE, Cox VS, Carey KD, Hook RR Jr. Congenital cutaneous and visceral melanomas of Sinclair miniature swine: Three case reports. J Natl Cancer Inst 1974, 52, 1559-1566 https://doi.org/10.1093/jnci/52.5.1559
  16. Meuten DJ. Tumors in domestic animals. 4th ed. pp. 78-81, Iowa state press, Iowa, 2002
  17. Monlux AW, Anderson WA, Davis CL. A survey of tumors occurring in cattle, sheep and swine. Am J Vet Res 1956, 17, 646-677
  18. Nordby JE. Congenital melanotic skin tumors in swine. J Hered 1933, 24, 361-364 https://doi.org/10.1093/oxfordjournals.jhered.a103830
  19. Ruth GR, Horstmann JP, Lanin DR, Flynn K, Wang N, Hordinski M, Savino D. Spontaneous regression of cutaneous melanotic tumors in Duroc pigs. 23rd Annu Proc Am Assoc Vet Lab Diagnost 1980, 381-390
  20. Smith GD, Oxenhandler RW, Berkelhammer J, Middleton CC, Hook RR Jr. Lymph node morphology associated with malignant melanoma in Sinclair miniature swine. Proc Am Assoc Cancer Res 1981, 22, 324
  21. Strafuss AC, Dommert AR, Tumbleson ME, Middleton CC. Cutaneous melanomas in miniature swine. Lab Anim Care 1968, 18, 165-169
  22. Thirloway L, Rudolph R, Leipold HW. Malignant melanomas in a Duroc boar. J Am Vet Med Assoc 1977, 170, 345-347