Parasites, Hosts and Diseases

  • 제44권2호
  • /
  • Pages.163-166
  • /
  • 2006
  • /
  • 2982-5164(pISSN)
  • /
  • 1738-0006(eISSN)
대한기생충학·열대의학회 (The Korea Society for Parasitology and Tropical Medicine)
권호 표지

Susceptibility of experimental animals to reinfection with Clonorchis sinensis

  • Sohn, Woon-Mok (Department of Parasitology and Institute of Health Sciences, Gyeongsang National University College of Medicine) ;
  • Zhang, Hong-Man (Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine, and Institute of Endemic Diseases, Seoul National University Medical Research Center) ;
  • Choi, Min-Ho (Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine, and Institute of Endemic Diseases, Seoul National University Medical Research Center) ;
  • Hong, Sung-Tae (Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine, and Institute of Endemic Diseases, Seoul National University Medical Research Center)
  • 발행 : 2006.06.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

The present study observed the resistance to reinfection with Clonorchis sinensis in various experimental animals including mice, guinea pigs, rabbits, and dogs, as well as rats and hamsters. The resistance rates to reinfection in rats, mice, hamsters, guinea pigs, rabbits, and dogs were 79.7%, 58.0%, -12.6%, 54.8%, 62.6%, and 6.0%, respectively. Worms recovered from reinfected rats and mice were immature, and significantly smaller than those from the primarily infected (P < 0.01), whereas those from other animals were fully matured to adults. These findings indicate that the protective response against reinfection with C. sinensis is prominent in rats and mice, and that they may be a good animal model to investigate the mechanism of resistance to reinfection with C. sinensis.

키워드

참고문헌

  1. Cetre C, Pierrot C, Cocude C, Lafitte S, Capron A, Capron M, Khalife J (1999) Profiles of Th1 and Th2 cytokines after primary and secondary infection by Schistosoma mansoni in the semipermissive rat host. Infect Immun 67: 2713-2719
  2. Choi YK, Yoon BI, Won YS, Lee CH, Hyun BH, Kim HC, Oh GT, Kim DY (2003) Cytokine responses in mice infected with Clonorchis sinensis. Parasitol Res 91: 87-93 https://doi.org/10.1007/s00436-003-0934-2
  3. Chung BS, Zhang H, Choi MH, Jeon D, Li S, Lee M, Hong ST (2004) Development of resistance to reinfection by Clonorchis sinensis in rats. Korean J Parasitol 42: 19-26 https://doi.org/10.3347/kjp.2004.42.1.19
  4. Claerebout E, Vercruysse J (2000) The immune response and the evaluation of acquired immunity against gastrointestinal nematodes in cattle: a review. Parasitology 120(Suppl): 525-42
  5. Doy TG, Hughes DL, Harness E (1978) Resistance of the rat to reinfection with Fasciola hepatica and the possible involvement of intestinal eosinophil leucocytes. Res Vet Sci 25: 41-44
  6. Flavell DJ (1982) Acquired resistance to Opisthorchis viverrini in the hamster. Trans R Soc Trap Med Hyg 76: 800-802 https://doi.org/10.1016/0035-9203(82)90112-2
  7. Flavell DJ, Pattanapanyasat K, Flavell SU (1980) Opisthorchis viverrini: partial success in adoptively transferring immunity with spleen cells and serum in the hamster. J Helminthol 54: 191-197 https://doi.org/10.1017/S0022149X0000657X
  8. Garcia EG, Mitchell GF, Tiu WU, Tapales FP, Valdez CA (1983) Resistance to reinfection with Schistosoma japonicum in the mouse. Southeast Asian J Trop Med Public Health 14: 133-139
  9. Hong SJ, Lee YH, Chung MH, Lee DH, Woo HC (1994) Egg positive rates of Clonorchis sinensis and intestinal helminths among residents in Kagye-ri, Saengbiryangmyon, Sanchong-gun, Kyongsangnam-do. Korean J Parasitol 32: 271-273 https://doi.org/10.3347/kjp.1994.32.4.271
  10. Sirisinha S, Tuti S, Tawatsin A, Vichasri S, Upatham ES, Bunnag D (1983) Attempts to induce protective immunity in hamsters against infection by a liver fluke of man (Opisthorchis viverrini). Parasitology 86(Pt 1): 127-136 https://doi.org/10.1017/S0031182000057231
  11. Talvik H, Christensen CM, Nansen P (1998) Oesophagostomum spp. in pigs: resistance to reinfection. Parasitol Res 84: 783-786 https://doi.org/10.1007/s004360050488