Systemic Amyloidosis in a Cocker Spaniel

Cocker spaniel 견에서 발생한 전신성 아밀로이드증

  • Pak Son-Il (College of Veterinary Medicine, Kangwon National University) ;
  • Kim Doo (College of Veterinary Medicine, Kangwon National University) ;
  • Han Jeong-Hee (College of Veterinary Medicine, Kangwon National University)
  • 박선일 (강원대학교 수의학과 동물의학종합연구소) ;
  • 김두 (강원대학교 수의학과 동물의학종합연구소) ;
  • 한정희 (강원대학교 수의학과 동물의학종합연구소)
  • Published : 2006.06.01

Abstract

A 7-month-old female Cocker spaniel dog was examined for chronic anemia. Based on information provided by local clinician the patient had had a 'flu-like' illness three weeks before submission of the sample, had a fever of $40.9^{\circ}C$, and had mild hepatomegaly. This dog had also history of weight loss, vomiting, anorexia, dehydration, lethargy, ascites, polyuria and polydipsia. A blood smear showed non-regenerative anemia. Thoracic radiograph showed irregular shadowing in the left mid-zone. Serum biochemical results showed a hypercalcemia, azotemia, hypercholesterolemia, hyperphosphatemia, hypoalbuminemia, and metabolic acidosis. Results of urinalysis showed proteinuria, slightly acidic with isosthenuria. Histopathologic examination of tissue sections revealed amyloid deposits in multiple sites including kidneys, liver and spleen.

7개월된 암컷 Cocker spaniel견이 3주전부터 체중감소, 구토, 탈수, 식욕저하를 보이면서 지속적인 미열을 동반한 다음과 다뇨를 주증상으로 시내 병원에 내원하였다. 담당 수의사의 진료내역을 검토한 결과 복수와 간종대, 혈액 도말 검사에서 비재생성빈혈과 흉부방사선 사진에서 좌측 중심부에 불규칙한 음영이 관찰된 것으로 기록되었다. 이후 prednisolone으로 치료하였지만 증상의 경과가 호전되지 않아 정밀진단을 위하여 환자의 혈액을 강원대학교 부속동물 병원에 분석, 의뢰하였다. 혈액화학검사에서 고칼슘혈증, 고질소혈증, 콜레스테롤혈증, 고인혈증, 저알부민혈증 및 대사성 산증을 보였으며 뇨검사에서 단백뇨를 동반한 약산성의 등장뇨가 관찰되었다. 임상증상과 실험실 소견에 근거하여 간과 신장에 대한 정밀한 검사를 위하여 입원을 요청하였으나 다음 날 환자는 폐사한 상태로 병원에 후송되었다. 보호자의 동의를 얻어 부검과 조직병리학적인 검사를 실시한 결과 간, 신장, 비장 등의 전신 장기에 과량의 아밀로이드가 침착되어 있음을 확인하였다.

Keywords

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