Toxicological Research

  • 제22권2호
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  • Pages.69-74
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  • 2006
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  • 1976-8257(pISSN)
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  • 2234-2753(eISSN)
한국독성학회 (Korean Society of Toxicology & Korea Environmental Mutagen Society)
권호 표지

한국인 집단에서 심방 나트륨 이뇨 펩티드 유전자에 존재하는 유전적 변이와 본태성 고혈압과의 관련성에 관한 연구

Association Study between the Genetic Variants of the Human Atrial Natriuretic Peptide Gene and Essential Hypertension in Korean Population

  • 배준설 (연세대학교 이과대학 생화학과) ;
  • 강병용 (삼육대학교 생명과학연구소) ;
  • 이강오 (삼육대학교 생명과학연구소) ;
  • 이승택 (연세대학교 이과대학 생화학과)
  • Bae Joon-Seol (Department of Biochemistry, College of Science, Yonsei University) ;
  • Kang Byung-Yong (Research Institute for Life Science, Sahmyook University) ;
  • Lee Kang-Oh (Research Institute for Life Science, Sahmyook University) ;
  • Lee Seung-Taek (Department of Biochemistry, College of Science, Yonsei University)
  • 발행 : 2006.06.01
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초록

Hypertension leads to major health problems in many industrialized countries, and multiple etiologic factors are involved in the pathogenesis of this disorder. The genetic components of the natriuretic peptide system might be involved in the pathogenesis of hypertension. In this regard, the atrial natriuretic peptide (ANP) gene has been proposed as a candidate hypertension gene. Therefore, we investigated the G1837A and C-664G polymorphisms of the ANP gene in 143 Korean normotensives and 118 hypertensives. There were no significant differences in the genotype and allele frequencies between the two groups. Although the frequencies in each of these polymorph isms were not significantly different between normotensives and hypertensives, our results provide additional ethnic information for linkage analysis and associated studies of this disorder with cardiovascular disease.

키워드

참고문헌

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