Journal of the East Asian Society of Dietary Life (동아시아식생활학회지)

The East Asian Society of Dietary Life (동아시아식생활학회)
권호 표지

Effects of Diet with Added Butterbur (Petasites japonicus Maxim) on the Plasma Lipid Profiles and Antioxidant Index of Mice

머위(Petasites japonicus Maxim) 첨가 식이가 마우스 혈장 지질 수준 및 항산화 지표에 미치는 영향

  • Oh Sang-Hee (Dept. of Food and Nutrition, Chungnam National University) ;
  • Yang Yun-Hyung (Dept. of Food and Nutrition, Chungnam National University) ;
  • Kwon Oh-Yoon (Dept. of Food and Nutrition, Chungnam National University) ;
  • Kim Mee-Ree (Dept. of Food and Nutrition, Chungnam National University)
  • 오상희 (충남대학교 식품영양학과) ;
  • 양윤형 (충남대학교 식품영양학과) ;
  • 권오윤 (충남대학교 식품영양학과) ;
  • 김미리 (충남대학교 식품영양학과)
  • Published : 2006.08.01
Download PDF
⟨ Previous Next ⟩

Abstract

We evaluated the effects of butterbur (Petasites japonicus Maxim) addition to the diet on lipid profiles and antioxidant biomarkers such as total glutathionine, TBARS value, carbonyl value, GPx, GR, SOD and paraoxonase activity in the plasma or liver of mice. The distribution of body fat deposition, total cholesterol (TC) contents, and atherogenic index in the plasma were significantly decreased in the butterbur group. The levels of GSH and the activity of GR and SOD were significantly higher in the liver of the butterbur group than in that of the control group. Lipid oxidation of the liver and kidney and protein oxidation of the liver and heart were decreased in the butterbur group. Additionally, the DNA damage, as determined using the comet assay (single cell gel assay) with alkaline electrophoresis and as quantified by measuring the tail length (TL), was decreased in the butterbur group. The results of the present study showed that a diet with added butterbur exerts degenerative disease-protective effects on oxidative DNA damage and lipid peroxidation.

Keywords