The Camellia sinensis Inhalation Effects of Pulmonary Structure Protection and Anti-oxidants Enzyme from Cigarette Smoking

  • Kim Sang-Gi (Department of Biochemistry, Kyungpook National University) ;
  • Jung Hyuk (Department of Biochemistry, Kyungpook National University) ;
  • Kim Bo-Ae (Department of Biochemistry, Kyungpook National University) ;
  • Choi Yoong-Suk (Department of Biochemistry, Kyungpook National University) ;
  • Kim Sang-Kook (Department of Biochemistry, Kyungpook National University) ;
  • Choi Gui-Hyang (Department of Biochemistry, Kyungpook National University) ;
  • Park Jong-Seok (Department of Clinical Pathology, Daegu Health College) ;
  • Suh Tae-Soo (Department of Physical Therapy, Daegu Health College) ;
  • Kim You-Young (Department of Biochemistry, Kyungpook National University)
  • 발행 : 2006.09.01

초록

Cigarette smoke causes atypical structure of pulmonary and oxidative damage. Therefore, we carried out to determine if exposure to cigarette smoke alters pulmonary structure and anti-oxidant related enzyme in a animal model, when natural product extracts using by Nebulizer. The rat were divided into four groups: $H_2O-treated$ (Control), natural product (Camellia sinensis) extracts-treated (CS), natural product extracts-treated with cigarette smoke-exposed (CS+SM) and cigarette smoke-expose (SM). All groups are similar to Control group in weight, but SM group is lower than the other groups. Microscopic image of the pulmonary structure in SM group showed deleterious alterations in the morphology, but the other groups are maintained in normal structure. In anti-oxidant related enzymes, SOD (superoxide dismutase) and catalase, SM group represents the lowest enzyme activity among all groups. But G6PD (glucose-6-phosphate dehydrogenase) and LPO (lipid peroxidation) is SM group represents the highest enzyme activity among all groups. These result indicate that the natural product extracts is an efficient tissue protective substance against smoke-induced lung injury.

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