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A study on clinical efficacy of Abutilon indicum in treatment of bronchial asthma

  • Published : 2006.12.31

Abstract

The present investigation was carried out to determine the efficacy and safety of Abutilon indicum (A. indicum) (Eng: Country Mallow, Fam: Malvaceae) in patients of bronchial asthma. Dried aerial parts of A. indicum were finely powdered and given in the dose of 1 gm tid to 30 patients of either sex in the range of 15 - 80 years with mild to moderate bronchial asthma with or without any concurrent medication. The respiratory functions (FVC, $FEV_{1}$, $FEF_{25-75%}$and MVV) were assessed using a spirometer prior to and after 4 weeks of treatment. Efficacy of the drug in improving clinical symptoms and severity of asthmatic attacks was evaluated by interviewing the patient and by physical and hematological examination at the end of the treatment. 4 weeks treatment with the drug showed statistically significant improvement in various parameters of pulmonary functions in asthmatic subjects. Also significant improvement was observed in clinical symptoms and severity of asthmatic attacks. None of the patient showed any adverse effect with A. indicum. The results of the present study suggest the usefulness of A. indicum in patients with mild to moderate bronchial asthma.

Keywords

References

  1. Anjuli N, Robert L, Steven W, Patti S, Michael W. (2002) Efficacy and Safety of Beclomethasone Dipropionate Extrafine Aerosol in Childhood Asthma. A 12-Week, Randomized, Double-Blind, Placebo-Controlled Study. Chest 122, 1956-1965. https://doi.org/10.1378/chest.122.6.1956
  2. Bethesda MD. (1995) Global strategy for asthma management and prevention. Global initiative for asthma. National Institutes of Health 95, 3659.
  3. Bethesda MD. (1997) National Asthma Education and Prevention Program (National Heart, Lung, and Blood Institute) Second Expert Panel on the Management of Asthma. Expert panel report 2: guidelines for the diagnosis and management of asthma: National Institutes of Health 97, 4051.
  4. Chopra RN, Nayar SL, Chopra LC. (1986) Glossary of Indian Medicinal Plants (Including the Supplement) pp. 152-153, Council of Scientific and Industrial Research, New Delhi.
  5. Djukanovic R, Wilson TW, Britten KM, Wilson SJ, Walls AF, Roche WR. (1992) Effect of an inhaled corticosteroid on airway inflammation and symptoms in asthma. Am. Rev. Respir. Dis. 145, 669-674.
  6. Dorsch W, Stuppner H, Wagner H, Gropp M, Demolin S, Ring J. (1991) Antiasthmatic effects of Picorrhiza Kurroa: androsin prevents allergen and PAP induced bronchial obstruction in guinea pigs. Int. Arch. Allergy Appl. Immunol. 95, 128-133. https://doi.org/10.1159/000235416
  7. Fireman P. (2003) Understanding asthma patho-physiology. Allergy Asthma Proc. 24, 79-83.
  8. Harczy M, Maclouf J, Pradelles P, Braquet P, Borgeat P, Sirois P. (1986) Inhibitory effects of a novel platelet activating factor (PAF) antagonist (BN 52021) on antigen-induced prostaglandin and thromboxane formation by the guinea pig lung. Pharmacol. Res. Commun. 18, 111-117.
  9. Horwitz RJ, Busse WW. (1995) Inflammation and asthma. Clin. Chest Med. 16, 583-620.
  10. Mehta BK, Neogi R, Kotra S, Mall OP. (1997) Antimicrobial activity of Abutilon indicum. Fitoterapia 68, 273-274.
  11. Nadkarni KM. (1954) The Indian Materia Medica pp. 8-9, Dhootapapeshwar Prakashan Ltd., Panvel, India.
  12. Rob P, David P. (2002) The Measurement and Interpretation of Ventilatory Function in Clinical Practice. In: Spirometry Handbook , pp. 3.
  13. Safayhi H, Mack T, Sabieraj J, Anazodo MI, Subramanian LR, Ammon HP. (1992) Boswellic acids: novel, specific, nonredox inhibitors of 5-lipoxygenase. J. Pharmacol. Exp. Ther. 261, 1143-1146.
  14. Sharma PV, Ahmed ZA, Sharma W. (1989) Analgesic constituent of Abutilon indicum. Indian drugs 26, 333.
  15. Sharma R, Kumar A, Tewari PV. (1993) Ayurvedic approach in prevention of upper respiratory tract infections in children. J. Res. Educ. Indian Med. 12, 15-26.
  16. Vishwanathan MB. (1995) A note on some medicinal plants of the alagarkovil MPCA in Tamilnadu. Industry Meet cum Seminar on Biodiversity and information on medicinal and aromatic plants, New Delhi 60-61.