Journal of Korean Traditional Oncology (대한암한의학회지)

Korean Association of Traditional Oncology (대한암한의학회)
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The Study on the Process and Quality Control of Rhus Verniciflua Stokes Extract (Nexia)

건칠(乾漆) 추출물(Nexia)의 Quality Control을 위한 기시법 및 안정성 연구

  • Park, Sang-Jae (AZI company) ;
  • Kim, Kyung-Suk (MU Integrative Cancer Center, East-West Medical Center, Kyung Hee University) ;
  • Jung, Hyun-Sik (MU Integrative Cancer Center, East-West Medical Center, Kyung Hee University) ;
  • Choi, Won-Cheol (MU Integrative Cancer Center, East-West Medical Center, Kyung Hee University) ;
  • Yoon, Seong-Woo (Department of Oriental Internal Medicine, College of Oriental Medicine, Kyung Hee University, MU Integrative Cancer Center, East-West Medical Center, Kyung Hee University)
  • 박상재 (AZI(주)) ;
  • 김경석 (경희대학교 동서신의학병원 통합암센터) ;
  • 정현식 (경희대학교 동서신의학병원 통합암센터) ;
  • 최원철 (경희대학교 동서신의학병원 통합암센터) ;
  • 윤성우 (경희대학교 한의과대학 한방내과, 경희대학교 동서신의학병원 통합암센터)
  • Published : 2006.12.29
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Abstract

Rhus Verniciflua Stokes has been used for long history to treat blood stasis and cancer in Oriental Medicine. But urushiol, a constituent of Rhus Verniciflua Stokes has T-cell mediated allergic reaction, so it has made clinical limitation. Nexia is allergen removed extract of Rhus Verniciflua Stokes and its extraction process as well as quality control is needed to be standardized. The optimized extraction condition is as follow; temperature is $90{\sim}95^{\circ}C$, volume of slovent 10 times, extraction time >6 hours, pressure $, slovnet water or EtOH(60%), yield 8.1${\sim}$9.8(w/w). HPLC pattern and isolation study showed Nexia contain fisetin(>13.0%), fustin(>7.0%) and no urushiol.

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