Journal of Korean Traditional Oncology (대한암한의학회지)

Korean Association of Traditional Oncology (대한암한의학회)
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Angiogenic Inhibition Effects of Several Herbs Supplementing Qi and Blood

수종(數種) 보기보혈(補氣補血) 한약(韓藥)의 혈관신생(血管新生) 억제효과(抑制效果)

  • Lee, Jin-Wha (Department of Oriental Pathology, College of Oriental Medicine, Kyung Hee University, Institute of Oriental Medicine, Kyunghee University) ;
  • Kim, Han-Young (Department of Oriental Pathology, College of Oriental Medicine, Kyung Hee University, Institute of Oriental Medicine, Kyunghee University) ;
  • Kang, Hee (Department of Oriental Pathology, College of Oriental Medicine, Kyung Hee University, Institute of Oriental Medicine, Kyunghee University) ;
  • Yu, Young-Beob (Department of Oriental Pathology, College of Oriental Medicine, Kyung Hee University, Institute of Oriental Medicine, Kyunghee University) ;
  • Shim, Bum-Sang (Department of Oriental Pathology, College of Oriental Medicine, Kyung Hee University, Institute of Oriental Medicine, Kyunghee University) ;
  • Kim, Sung-Hoon (Department of Oriental Pathology, College of Oriental Medicine, Kyung Hee University, Institute of Oriental Medicine, Kyunghee University) ;
  • Choi, Seung-Hoon (Department of Oriental Pathology, College of Oriental Medicine, Kyung Hee University, Institute of Oriental Medicine, Kyunghee University) ;
  • Ahn, Kyoo-Seok (Department of Oriental Pathology, College of Oriental Medicine, Kyung Hee University, Institute of Oriental Medicine, Kyunghee University)
  • 이진화 (경희대학교 한의과대학 병리학교실, 경희대학교 한의학연구소) ;
  • 김한영 (경희대학교 한의과대학 병리학교실, 경희대학교 한의학연구소) ;
  • 강희 (경희대학교 한의과대학 병리학교실, 경희대학교 한의학연구소) ;
  • 유영법 (경희대학교 한의과대학 병리학교실, 경희대학교 한의학연구소) ;
  • 심범상 (경희대학교 한의과대학 병리학교실, 경희대학교 한의학연구소) ;
  • 김성훈 (경희대학교 한의과대학 병리학교실, 경희대학교 한의학연구소) ;
  • 최승훈 (경희대학교 한의과대학 병리학교실, 경희대학교 한의학연구소) ;
  • 안규석 (경희대학교 한의과대학 병리학교실, 경희대학교 한의학연구소)
  • Published : 2006.12.29
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Abstract

Two of the essential processes required for metastasis are neoangiogenesis and tumor cell invasion of basement membranes (BM) and extracellular matrix (ECM). Recently, data showed that herbs removing blood stasis has an anti-angiogenic effects. Tonifying vital Qi and eliminating pathogenic factor was a basic modality in Oriental oncology. In this study, we investigated several Qi and Blood tonics for potent angiogenic inhibitors. Methanol extracts of samples inhibited the proliferation of ECV-304 at the concentration of 100 ${\mu}g/m{\ell}$. Zizyphi Fructus, Glycyrrhizae Radix, Angelicae Gigantis Radix decreased the gelatinolytic activity of MMP-9 from ECV-304, at the concentration of 100 ${\mu}g/m{\ell}$ in gelatin zymography. In in vitro invasion assay, herbs inhibited the invasion activity of ECV-304 by 53% of control (Ginseng Radix), 39% (Zizyphi Fructus), 36% (Angelicae Gigantis Radix), 25% (Glycyrrhizae Radix). Ginseng Radix inhibited the capillary-like tube formation of ECV-304 at the concentration of 160 ${\mu}g/m{\ell}$, Angelicae Gigantis Radix and Paeoniae Radix Alba inhibited at the concentration of 320 ${\mu}g/m{\ell}$. These results indicated that Ginseng Radix, Glycyrrhizae Radix, and Angelicae Gigantis Radix could be considered as potent angiogenic inhibitiors.

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