The Korea Journal of Herbology (대한본초학회지)
- Volume 21 Issue 4
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- Pages.197-205
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- 2006
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- 1229-1765(pISSN)
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- 2288-7199(eISSN)
Novel animal model for brain atrophy and protective effects of Korean ginseng
새로운 뇌 위축 동물 모델과 그 모델에서의 고려인삼의 보호 효과
- Kim, Myung-Gyou (College of Pharmacy, Woosuk University) ;
- Lee, Se-Na (College of Korean Medicine, Semyung University) ;
- Kim, Hyun-Mi (College of Pharmacy, Woosuk University) ;
- Chung, Joo-Ho (Kohwang Medical Research Institute, Kyung Hee University) ;
- Leem, Kang-Hyun (College of Korean Medicine, Semyung University)
- Published : 2006.12.30
Abstract
Objectives: Anti-oxidants are known to prevent neuronal diseases with pathological and physiological changes such as the brain atrophy and cognitive impairment. This study was designed to investigate the protective effects of Korean ginseng on the oxidative stress induced pathologic changes, and develop new animal model for the brain atrophy. Korean ginseng has anti-oxidant, anti-aging, and protective effects on the brain ischemia. Methods : The intracerebroventricular (ICV) hydrogen peroxide (