Bulletin of the Korean Chemical Society

  • 제28권5호
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  • Pages.777-782
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  • 2007
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  • 0253-2964(pISSN)
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  • 1229-5949(eISSN)
대한화학회 (Korean Chemical Society)
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A General Strategy for the Synthesis of Amino-Substituted 2-Pyridones Using a Palladium-Catalyzed Amination Reaction

  • Kim, Young-Ha (Department of Chemistry, Chungnam National University) ;
  • Kim, Yeong-Joon (Department of Chemistry, Chungnam National University) ;
  • Chang, Sung-Youn (Center for Medicinal Chemistry, Korea Research Institute of Chemical Technology) ;
  • Kim, Bum-Tae (Center for Medicinal Chemistry, Korea Research Institute of Chemical Technology) ;
  • Heo, Jung-Nyoung (Center for Medicinal Chemistry, Korea Research Institute of Chemical Technology)
  • 발행 : 2007.05.20
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초록

A novel library of amino-substituted 2-pyridones has been constructed through a two-step sequence of microwave-promoted Buchwald-Hartwig amination of 2-benzyloxy halopyridines followed by debenzylation. Microwave-promoted amination of 3- or 4-halopyridine in the presence of a suitable palladium catalyst and ligand system provided amino-substituted 2-benzyloxypyridines in excellent yields. Then, debenzylation of 2- benzyloxypyridines afforded the corresponding 2-pyridones with high efficiency.

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참고문헌

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