Bulletin of the Korean Chemical Society

  • 제28권1호
  • /
  • Pages.63-67
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  • 2007
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  • 0253-2964(pISSN)
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  • 1229-5949(eISSN)
대한화학회 (Korean Chemical Society)
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Synthesis and Characterization of Degradable Polycationic Polymers as Gene Delivery Carriers

  • Kim, Hyun-Jin (School of Chemistry & Molecular Engineering, Seoul National University) ;
  • Kwon, Min-Sung (School of Chemistry & Molecular Engineering, Seoul National University) ;
  • Choi, Joon-Sig (Department of Biochemistry, Chungnam Natiional University) ;
  • Kim, Bo-Hye (School of Chemistry & Molecular Engineering, Seoul National University) ;
  • Yoon, Jae-Keun (School of Chemistry & Molecular Engineering, Seoul National University) ;
  • Kim, Kwan (School of Chemistry & Molecular Engineering, Seoul National University) ;
  • Park, Jong-Sang (School of Chemistry & Molecular Engineering, Seoul National University)
  • 발행 : 2007.01.20
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초록

Biodegradable cationic poly(ester-amide) polymers were synthesized by double-monomer method, that showed excellent solubility in many organic solvents and water. Different degradation patterns were obtained by the regulation of monomer ratios and overall long period of time of DNA protection up to 12 days was shown by PicoGreen reagent assay. Good transfection profiles in the presence of serum and very low toxicity on mammalian cells may allow these polymers to become suitable for long-term gene delivery systems and therapeutic applications.

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참고문헌

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피인용 문헌

  1. Biophysical characterization of quaternary pyridinium functionalized polynorbornenes for DNA complexation and their cellular interactions vol.107, pp.4, 2017, https://doi.org/10.1002/bip.23005
  2. Advanced Materials for Gene Delivery vol.995, pp.1662-8985, 2014, https://doi.org/10.4028/www.scientific.net/AMR.995.29
  3. Enhancement of the Transfection Efficiency of Poly(ethylenimine) by Guanidylation vol.29, pp.3, 2007, https://doi.org/10.5012/bkcs.2008.29.3.666
  4. Analysis of the Relationship between the Molecular Weight and Transfection Efficiency/Cytotoxicity of Poly-L-arginine on a Mammalian Cell Line vol.30, pp.4, 2007, https://doi.org/10.5012/bkcs.2009.30.4.927
  5. In vitro Gene Delivery to HepG2 Cells with a Novel Galactosylated Polyornithine vol.30, pp.7, 2007, https://doi.org/10.5012/bkcs.2009.30.7.1622
  6. Novel amphiphilic block-copolymer forming stable micelles and interpolyelectrolyte complexes with DNA for efficient gene delivery vol.70, pp.8, 2007, https://doi.org/10.1080/00914037.2020.1740988