Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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[ ${\alpha}$ ]-Amylase and Protein Tyrosine Phosphatase 1B Inhibitory of Some Vietnamese Medicinal Plants Used to Treat Diabetes

  • Hung, Tran Manh (College of Pharmacy, Chungnam National University) ;
  • Manh, Hoang Duc (Korea Research Institute of Bioscience and Biotechnology) ;
  • Minh, Pham Thi Hong (Institute of Chemistry, Vietnamese Academy of Science and Technology) ;
  • Youn, Ui-Joung (College of Pharmacy, Chungnam National University) ;
  • Na, Min-Kyun (Korea Research Institute of Bioscience and Biotechnology) ;
  • Oh, Won-Keun (Korea Research Institute of Bioscience and Biotechnology) ;
  • Min, Byung-Sun (College of Pharmacy, Catholic University of Daegu) ;
  • Bae, Ki-Hwan (College of Pharmacy, Chungnam National University)
  • Published : 2007.12.31
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Abstract

In this study, the twenty-four ethyl acetate extracts of twenty-two medicinal plants, traditionally used in Vietnam as anti-diabetes agents, were investigated for ${\alpha}$-amylase and protein tyrosine phosphatase 1B (PTP1B) enzymes inhibitory activity in vitro. The results indicated that, twelve materials (50.0%) showed moderate to strong inhibitory activity in ${\alpha}$-amylase inhibitory activity with $IC_{50}$ values ranging from 2.5 to $48.8{\mu}g/mL$; meanwhile, ten extracts (41.6%) could demonstrate PTP1B activity with $IC_{50}$ values less than $30.5{\mu}g/mL$. Some plants presented interesting activities against both of ${\alpha}$-amylase and PTP1B enzymes such as Catharanthus roseus, Carthamus tinctorius, Momordica charantia, Gynostemma pentaphyllum, Glycyrrhiza glabra, Smilax glabra, Psidium guajava (leave), and Rehmannia glutinosa. The study may provide a proof, at least in a part, for the ethno-medical use in diabetes disease of these plants.

Keywords

References

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