Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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[ ${\alpha}$ ]-Amyrin Triterpenoids and Two Known Compounds with DNA Topoisomerase I Inhibitory Activity and Cytotoxicity from the Spikes of Prunella vulgaris var. lilacina

  • Byun, Soon-Jung (Department of Pharmacy, College of Pharmacy, Catholic University of Daegu) ;
  • Fang, Zhe (Department of Pharmacy, College of Pharmacy, Catholic University of Daegu) ;
  • Jeong, Su-Yang (Department of Pharmacy, College of Pharmacy, Catholic University of Daegu) ;
  • Lee, Chong-Soon (Department of Biochemistry, College of Natural Sciences, Yeungnam University) ;
  • Son, Jong-Keun (Department of Pharmacy, College of Pharmacy, Yeungnam University) ;
  • Woo, Mi-Hee (Department of Pharmacy, College of Pharmacy, Catholic University of Daegu)
  • Published : 2007.12.31
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Abstract

Three known ${\alpha}$-amyrin triterpenoids, ursolic acid (1), $2{\alpha},3{\alpha}$-dihydro xyurs-12-ene-28-oic acid (2) and euscaphic acid (3), and ${\beta}$-amyrin triterpenoid, $3{\beta}$-hydroxyolean-5,12-diene (4), and ${\alpha}$-spinasterol (5) have been isolated from the fractionated n-butanol extracts of the spikes of Prunella vulgaris var. lilacina, guided by DNA topoisomerases I and II inhibitory activities and cytotoxic activity against human cancer cells. Their structures were elucidated on the basis of spectroscopic and chemical methods. Compound 4 exhibited significant cytotoxic activity against human colon adenoblastoma (HT-29), and 5 showed DNA topoisomerase I and II inhibitions.

Keywords

References

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