Journal of Radiation Protection and Research

The Korean Association for Radiation Protection (대한방사선방어학회)
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RADIOPROTECTIVE EFFECT OF ALGIN-OLIGOSACCHARIDE THROUGH MEASURING CASPASE-3 AND CASPASE-9 IN MICE

  • Choi, Seong-Kwan (Dept. of Radiological Science, Hanlyo University) ;
  • Jung, Woon-Kwan (Dept. of Nuclear Energy Technology, Chosun University) ;
  • Lee, Kyu-Soo (Dept. of Radiological Science, Hanlyo University) ;
  • Jang, Young-Il (Dept. of Radiological Technology, Kwangysng Health College) ;
  • Dong, Kyeong-Rae (Dept. of Radiological Technology, Kwangysng Health College)
  • Published : 2007.12.30
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Abstract

In order to find out the Radioprotective effect of algin-oligosaccharide(AOS), this study, with a mouse of which whole frame irradiated by 3 Gy radiation once, measured caspase-3 and caspase-9 amid cell signaling connected to apoptosis in order to observe cell activation. In Caspase-3 and Caspase-9 test for observing cell activation, both of Caspase-3 and Caspase-9 showed highly increased O.D. value in the irradiation control group, while the whole groups treated with algin-oligosaccharide before or after irradiation indicated lower O.D. value than the irradiation control group, especially showed big difference in 7 day's treatment group of before irradiation (P<0.001). It confirmed that Caspase generation was restrained in AOS treatment group. Consequently, this study inquired into the fact that algin-oligosaccharide with superior antioxidant activity performed radiation protection by inducing restraint of Caspase generation and confirmed that natural product with less chemical toxicity was able to be applied as radioprotector.

Keywords

References

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