Toxicological Research

  • 제23권4호
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  • Pages.311-319
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  • 2007
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  • 1976-8257(pISSN)
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  • 2234-2753(eISSN)
한국독성학회 (Korean Society of Toxicology & Korea Environmental Mutagen Society)
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혈청호모시스테인 농도와 호모시스테인 유도성-세포 세네센스에 대한 표고버섯분말의 영향

Effects of Lentinus edodes-powder on Serum Homocysteine Level and Homocysteine-induced Replicative Senescence

  • 박영철 (대구가톨릭대학교 바이오안전성센터) ;
  • 김민희 (대구가톨릭대학교 바이오안전성센터) ;
  • 김종봉 (대구가톨릭대학교 자연대학 의생명과학과)
  • Park, Yeong-Chul (Center for Bio-Safety, Catholic University of Daegu) ;
  • Kim, Min-Hee (Center for Bio-Safety, Catholic University of Daegu) ;
  • Kim, Jong-Bong (Department of Medicinal Life Science, Catholic University of Daegu)
  • 발행 : 2007.12.31
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초록

Elevated blood levels of homocysteine (a sulfur-containing amino acid) have been linked to increased risk of cerebrovascular disease including Alzheimer's disease. A recent study suggests that elevated homocysteine levels may lead to replicative senescence in vitro called 'permanent arrest of cell cycle' caused by oxidative stress. In this study, serum homocysteine level in rat was reduced by Lentinus edodes-powder diet, resulting in the reduced level of oxidative stress in rat brain. In addition, homocysteine-induced replicative senescence treated with or without Lentinus edodes-powder was analyzed by population doubling in vitro. The Lentinus edodes-powder induced a increased number of population doubling in primary neuron cell isolated from rat-cerebral cortex. This indicates that Lentinus edodes-powder would delay a homocysteine-induced aging of neuron cells in brain, showing a possible role in preventing cerebrovascular diseases including Alzheimer's disease.

키워드

참고문헌

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