A Retrospective Study of 94 Hypercalcemic Dogs(2002-2004)

94 마리 고칼슘혈증 개들에 대한 회고연구(2002-2004)

  • Cho, Tae-Hyung (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Kang, Byeong-Teck (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Park, Chul (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Jung, Dong-In (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Yoo, Jong-Hyun (BK21 Program of Intergrative Network Systems for Veterinarians in Basic Science Industrial Animals and Preventive Medicines, College of Veterinary Medicine, Konkuk University) ;
  • Kim, Ju-Won (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Kim, Ha-Jung (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Lim, Chae-Young (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Lee, So-Young (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Kim, Jung-Hyun (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Woo, Eung-Je (College of Electronics and Information, Kyunghee University) ;
  • Park, Hee-Myung (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University)
  • 조태형 (건국대학교 수의과대학 내과학 교실) ;
  • 강병택 (건국대학교 수의과대학 내과학 교실) ;
  • 박철 (건국대학교 수의과대학 내과학 교실) ;
  • 정동인 (건국대학교 수의과대학 내과학 교실) ;
  • 유종현 (건국대학교 BK21 수의기초.산업동물.예방의학 통합네트워크 연구인력 양성 사업단) ;
  • 김주원 (건국대학교 수의과대학 내과학 교실) ;
  • 김하정 (건국대학교 수의과대학 내과학 교실) ;
  • 임채영 (건국대학교 수의과대학 내과학 교실) ;
  • 이소영 (건국대학교 수의과대학 내과학 교실) ;
  • 김정현 (건국대학교 수의과대학 내과학 교실) ;
  • 우응제 (경희대학교 전자정보대학 동서의료공학과) ;
  • 박희명 (건국대학교 수의과대학 내과학 교실)
  • Published : 2007.12.31

Abstract

A retrospective study of 94 hypercalcemic dogs was performed to find out most common causes that lead to hypercalcemia through investigating dogs referred to the Veterinary Teaching Hospital of Konkuk University from 2002 to 2004. During the study period, hypercalcemia was found in 94 dogs of 19 breeds, and they were evaluated as case group. Control group was made up of 94 dogs of 18 breeds without hypercalcemia admitted for the same study period. For general signalments, there were no significant differences between case and control group with the exception of age distribution. Shih-tzu(17.02%) and Yorkshire terrier(26.60%) was the most common breed in case and control group, respectively. The most common diseases associated with hypercalcemia were chronic renal failure (18.09%), acute renal failure(14.89%), and renal calculi(6.38%). Malignant neoplasia(lymphoma, hemangiosarcoma, chronic lymphocytic leukemia, mammary gland tumor, and multiple myeloma) and endocrinopathies(hyperadrenocorticism, hyperthyroidism, hypoadrenocorticism, and hypothyroidism) occupied 8.5% and 6.4%, respectively. This report is a first retrospective study of hypercalcemic dogs in South Korea.

2002년부터 2004년 까지 건국대학교 부속동물병원에 의뢰된 환축 중 고칼슘혈증견을 나타내는 94마리를 대상으로 원인질병을 조사하였다. 연구 기간 동안 고칼슘혈증은 총 94 마리, 19 견종에서 발견되었으며, 이들을 증례군에 포함시켰다. 대조군은 동일 연구기간 동안 고칼슘혈증이 발생되지 않은 총 94마리, 18 견종으로 구성되어졌다. 일반 품고 들에 대해서는 나이 분포를 제외하고는 증례군과 대조군 간에 현저한 차이가 없었다. 시츄(17.02%)와 요크셔 테리어(26.60%)가 증례군과 대조군에서 각각 가장 일반적인 품종이었다. 고칼슘혈증의 가장 일반적인 원인은 만성 신부전(14.89%) 이었으며, 그 다음으로 급성 신부전(14.89%), 신결석(6.38%)순이었다. 악성종양(림프종, 혈관육종, 만성 림프구성 백혈병, 유선 종양 및 다발성 골수종) 내분비계 질환(부신피질 기능항진증, 갑상선 기능항진증, 부신피질 기능저하증 및 갑상선 기능저하증)은 고칼슘혈증의 원인 중 8.5%와 6.4%를 각각 나타내었다.

Keywords

References

  1. Berger B, Feldman FC. Primary hyperparathyroidism in dogs: 21 cases (1976-1986). J Am Vet Med Assoc 1987; 191: 350-356
  2. Chew DJ, Capen CC. Calcium nephropathy and associated disorders. In: Kirk's Current veterinary therapy, VII 7th ed. Philadelphia: W. B. Saunders. 1980: 1067-1072
  3. Chew DJ, Carothers M. Hypercalcemia. Vet Clin North Am Small Anim Pract 1989; 19: 265-287 https://doi.org/10.1016/S0195-5616(89)50030-5
  4. Chew DJ, Meuten DJ. Disorders of calcium and phosphorous metabolism. Vet Clin North Am Small Anim Pract 1982; 12: 411-438 https://doi.org/10.1016/S0195-5616(82)50053-8
  5. Ebashi S. $Ca^{2+}$ in biological systems. Experientia 1985; 41: 978-981 https://doi.org/10.1007/BF01952117
  6. Kruger JM, Osborne CA, Nachreiner RF, Refsal KR. Hypercalcemia and renal failure. Etiology, pathophysiology, diagnosis, and treatment. Vet Clin North Am Small Anim Pract 1996; 26: 1417-1445 https://doi.org/10.1016/S0195-5616(96)50135-X
  7. Lauel EW, John MG, Richard KD, Jeffrey LJ, Rance MG, Douglas HT, Susan EL, Mary S, Antony SM. Carcinoma of the apocrine glands of the anal sac in dogs: 113 cases (1985-1995). J Am Vet Med Assooc 2003; 223: 825-831 https://doi.org/10.2460/javma.2003.223.825
  8. Martin LG. Hypercalcemia and hypermagnesemia. Vet Clin North Am Small Anim Pract 1998; 28: 565-585 https://doi.org/10.1016/S0195-5616(98)50056-3
  9. Mellanby RJ, Mee AP, Berry JL, Herrtage ME. Hypercalcaemia in two dogs caused by excessive dietary supplementation of vitamin D. J Small Anim Pract 2005; 46: 334-338 https://doi.org/10.1111/j.1748-5827.2005.tb00329.x
  10. Meuten DJ. Hypercalcemia. Vet Clin North Am Small Anim Pract 1984; 14: 891-910 https://doi.org/10.1016/S0195-5616(84)50088-6
  11. Meuten DJ, Chew DJ, Capen CC, Kociba GJ. Relationship of serum total calcium to albumin and total protein in dogs. J Am Vet Med Assoc 1992; 180: 63-67
  12. Nelson RW, Turnwald GH, Willard MD. Endocrine, metabolic, and lipid disorders. In: Small animal clinical diagnosis by laboratory methods. 4th ed. St. Louis: W. B. Saunders. 2004: 166-167
  13. Onions DE. A prospective survey of familial canine lymphosarcoma. J Natl Cancer Inst 1984; 72: 909-912
  14. O'Brien TD, Osborne CA, Yano BL, Barnes DM. Clinicopathologic manifestations of progressive renal disease in Lhasa Apso and Shih Tzu dog. J Am Vet Med Assoc 1982; 180: 658-664
  15. Peterson ME, Feinman JM. Hypercalcemia associated with hypoadrenocorticism in sixteen dogs. J Am Vet Med Assoc 1982; 181: 802-804
  16. Priester WA, McKay FW. The occurrence of tumors in domestic animal. J Natl Cancer Inst 1980; 54: 1-210
  17. Rosol TJ, Capen CC. Pathophysiology of calcium, phosphorus, and magnesium metabolism in animals. Vet Clin North Am Small Anim Pract 1996; 26: 1155-1184 https://doi.org/10.1016/S0195-5616(96)50060-4
  18. Rosol TJ, Chew DJ, Nagode LA, Capen CC. Pathophysiology of calcuim metabolism. Vet Clin Pathol 1995; 24: 49-63 https://doi.org/10.1111/j.1939-165X.1995.tb00937.x
  19. Ruslander DA, Gebhard DH, Tompkins MB, Grindem CB, Page RL. Immunophenotypic characterization of canine lymphoproliferative disorders. In Vivo 1997; 11: 169-172
  20. Sarah JL, Mark CW, Robert LG. Unusual IgM-secreting multiple myeloma in a dog. J Am Vet Med Assooc 2003; 223: 645-648 https://doi.org/10.2460/javma.2003.223.645
  21. Teske E, van Heerde P, Rutteman GR, Kurzman ID, Moore PF, MacEwen EG. Prognostic factors for treatment of malignant lymphoma in dogs. J Am Vet Med Assoc 1994; 205: 1722-1728
  22. Uehlinger P, Glaus T, Hauser B, Reusch C. Hypercalcemia in dogs – A retrospective study of 46 cases. Schweiz Arch Tierheilkd 1998; 140: 188-197
  23. Vail DM, MacEwen EG, Young KM. Canine lymphoma and lymphoid leukemias. In: Small animal clinical oncology, 3rd ed. Philadelphia: W. B. Saunders. 2001: 558-590
  24. Weir EC, Burtis WJ, Morris CA. Isolation of 16,000 dalton parathyroid hormone like proteins from two animal tumors causing humoral hypercalcemia of malignancy. Endocrinology 1988; 123: 2744-2751 https://doi.org/10.1210/endo-123-6-2744
  25. Willard MD, Schall WD, McCaw DE, Nachreiner RF. Canine hypoadrenocorticism: report of 37 cases and review of 39 previously reported cases. J Am Vet Med Assoc 1982; 180: 59-62