Journal of the Society of Cosmetic Scientists of Korea (대한화장품학회지)

Society of Cosmetic Scientists of Korea (대한화장품학회)
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Application as a Cosmeceutical Ingredient of Extract from Euphorbia jolkini

암대극 추출물의 화장품 원료로서의 특성

  • 이대우 ((주)참존 기술원 응용연구소) ;
  • 김영진 ((주)참존 기술원 응용연구소) ;
  • 김영실 ((주)참존 기술원 응용연구소) ;
  • 엄상용 ((주)참존 기술원 응용연구소) ;
  • 김종헌 ((주)참존 기술원 응용연구소)
  • Published : 2007.12.30
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Abstract

In this study, we evaluate anti-oxidation, whitening and anti-inflammatory efficacies of Euphorbia jolkini extract for application as a cosmeceutical ingredient. We separated 5 fractions from Euphorbia jolkini extract (70 % MeOH) by MPLC. First and 5th fractions showed a supressive effect on Mn-SOD synthesis in the normal human fibroblasts. They inhibited melanogensis in the B16-F10 melanma cells. Furthermore, 1st and 5th fractions reduced the amounts of $IL-1{\alpha}$, IL-6, COX-II and total NO secreted from the normal human fibroblasts. These results suggest that Euphorbia jolkini extract may be used as an active ingredient in cosmetics.

본 연구는 암대극 추출물의 화장품 원료로서의 특성을 알아보기 위하여 항산화, 미백 및 항염 효과와 관련된 다양한 실험을 실시하였다. 암대극 70 % 메탄올 추출물은 MPLC를 사용하여 5개의 분획들로 분리하였다. 1번과 5번 분획에서 항산화(Mn-SOD 생성 억제), 미백(세포 내 멜라닌 생성 억제) 그리고 항염($IL-1{\alpha}$, IL-6, COX-2, Total NO 생성 억제)효과를 나타내었다. 이러한 결과를 종합해 볼 때, 암대극 추출물은 화장품 원료로서의 개발이 기대된다.

Keywords

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