Archives of Plastic Surgery

Korean Society of Plastic and Reconstructive Surgeons (대한성형외과학회)
권호 표지

An Analysis of Clinical and Histopathological Pattern of Malignant Melanoma

최근 6년간 경험한 악성 흑생종의 임상병리조직학적 유형 분석

  • Choi, Soo Jong (Department of Plastic and Reconstructive Surgery, Pusan National University) ;
  • Bae, Yong Chan (Department of Plastic and Reconstructive Surgery, Pusan National University) ;
  • Moon, Jae Sul (Department of Plastic and Reconstructive Surgery, Pusan National University) ;
  • Nam, Su Bong (Department of Plastic and Reconstructive Surgery, Pusan National University) ;
  • Oh, Chang Gun (Department of Dermatology, Pusan National University) ;
  • Kwak, Hee Suk (Department of Surgery, Pusan National University) ;
  • Kim, Chang Won (Department of Radiology, Pusan National University)
  • 최수종 (부산대학교 의과대학 성형외과학교실) ;
  • 배용찬 (부산대학교 의과대학 성형외과학교실) ;
  • 문재술 (부산대학교 의과대학 성형외과학교실) ;
  • 남수봉 (부산대학교 의과대학 성형외과학교실) ;
  • 오창근 (부산대학교 의과대학 피부과학교실) ;
  • 곽희숙 (부산대학교 의과대학 외과학교실) ;
  • 김창원 (부산대학교 의과대학 진단방사선과학교실)
  • Received : 2007.03.16
  • Published : 2007.09.10
Download PDF
⟨ Previous Next ⟩

Abstract

Purpose: Malignant melanoma is a fatal tumor arising in the melanocytic systems of the skin. The incidence of malignant melanoma, formerly considered a rare tumor in Korea, is observed to increase. The aim of this study is to analyze the clinical and histopathological pattern of malignant melanoma in one institute. Methods: Thirty patients with ages ranging from 33 to 80 years, diagnosed as malignant melanoma at our skin tumor department, were enrolled in a retrospective study over a 6 year period(2000. 9-2006. 7). The analyzed data included age, sex, location, duration before diagnosis, clinical type, level of invasion, and stage. Results: The cases were identified and analyzed by clinical and histopathologic study. The male to female ratio was 1:1.7. Lower extremities(especially, feet) were favored sites. The majority of cases were acral lentiginous melanoma(40%), followed by nodular melanoma (36.7%), superficial spreading melanoma(20%) in this study. Clark level IV was predominant in histopathologic study. There was merely narrow gap among each stage by AJCC. Conclusion: The clinicopathological characteristic of melanoma in our patients is quite different with that in the West. In this retrospective study, primary lesions of the foot were predominant with melanoma, and a high percentage of these were classified pathologically as acral lentiginous melanomas. Patients had a more advanced stage of disease at first presentation and a more deeply invasive primary lesion than Western patients. These suggest that malignant melanoma has a worse prognosis in our patients than in the West. So, further organized prospective studies are needed to approach the prudent and accurate diagnosis and management of melanoma in Korea.

Keywords

Acknowledgement

Supported by : 부산대학교

References

  1. Reintgen DS, McCarty KM Jr, Cox E, Seigler HF: Malignant melanoma in black American and white American populations. A comparative review. JAMA 248: 1856, 1982 https://doi.org/10.1001/jama.248.15.1856
  2. Kukita A, Ishihara K: Clinical features and distribution of malignant melanoma and pigmented nevi on the sole of the feet in Japan. J Invest Dermatol 92: 210, 1989 https://doi.org/10.1111/1523-1747.ep12276738
  3. Collins RJ: Melanoma in the Chinese of Hong Kong. Emphasis on volar and subungual sites. Cancer 54: 1482, 1984 https://doi.org/10.1002/1097-0142(19841001)54:7<1482::AID-CNCR2820540745>3.0.CO;2-O
  4. Lee DH, Kim YC, Cho SH, Lee MG: Clinicopathologic analysis of malignant melanoma. Korean J Dermatol 40: 914, 2002
  5. Cho KH, Cho MK, Lee YS, Ham EK: Clinical and histopathologic study of acral melanoma. Korean J Dermatol 27: 388, 1989
  6. Won YH, Hur SG, Lee SC, Chunn IK, Kim YP: Clinical and histopathologic study of malignant melanoma. Korean J Dermatol 29: 193, 1991
  7. Langley RG, Barnhill RL, Mihm Jr. MC, Fitzpatrick TB, Sober AJ: Neoplasms, cutaneous melanoma. Freeberg IM, Eisen AZ, Wolff K, Austen KF, Goldsmith LA, Katz SI(eds): Fitzpatrick's Dermatology in General Medicine. 6th ed, New York, McGraw-Hill 2003, p 918
  8. Balch CM, Houghton AN, Sober AJ, Soong S: Cutaneous Melanoma. 3rd ed, Philadelphia, JB Lippincott, 1998, P 3
  9. Landis SH, Murray T, Bolden S, Wingo PA: Cancer statistics, 1998. CA Cancer J Clin 48: 6, 1998 https://doi.org/10.3322/canjclin.48.1.6
  10. Kheir SM, Bines SD, Vonroenn JH, Song SJ, Urist MM, Coon JS: Prognostic significance of DNA aneuploidy in stage I cutaneous melanoma. Ann Surg 207: 455, 1988 https://doi.org/10.1097/00000658-198804000-00014
  11. Silver HK, Karim KA, Le Riche J, de Jong G, Spinelli J, Worth A, McLean DI, Gallagher R: Nuclear DNA, serum sialic acid and measured depth in malignant melanoma for predictiong disease recurrence and survival. Int J Cancer 44: 31, 1989 https://doi.org/10.1002/ijc.2910440106