Cycad revoluta toxicosis in a dog

  • Accepted : 2007.05.11
  • Published : 2007.06.30

Abstract

A 3-year-old female Cocker Spaniel dog acutely developed hepatopathy following ingestion of root of Cycad (Cycas revoluta). Seven hours after the ingestion, she showed acute continuous nausea, vomiting, and marked depression and was presented to the local veterinary clinic. At physical evaluation, the dog showed moderate weakness, pale mucous membrane, jaundice, and dehydration. Serum biochemical analysis revealed elevated alanine aminotransferase and aspartate aminotransferase, and mild azotemia. The dog was treated with intravenous fluid, antibiotics, and hepatic protectants for 10 days and recovered without any sequela. Although the ingestion of Cycad in dogs is rare, it can be treated successfully with appropriate supportive therapy.

Keywords

References

  1. Albretsen JC, Khan SA, Richardson JA. Cycad palm toxicosis in dogs: 60 cases (1987-1997). J Am Vet Med Assoc 1998, 213, 99-101
  2. Botha CJ, Naude TW, Swan GE, Ashton MM, van der Wateren JF. Suspected cycad (Cycas revoluta) intoxication in dogs. J S Afr Vet Assoc 1991, 62, 189-190
  3. Dewey CW. Encephalopathies: disorders of the brain. In: Dewey CW (ed.). A Practical Guide to Canine and Feline Neurology. pp. 99-178, Brackwell Publishing Professional, Ames, 2003
  4. Gao M, Zhang J, Liu G. Effect of diphenyl dimethyl bicarboxylate on concanavalin A-induced liver injury in mice. Liver Int 2005, 25, 904-912 https://doi.org/10.1111/j.1478-3231.2005.01140.x
  5. Hall WT. Cycad (zamia) poisoning in Australia. Aust Vet J 1987, 64, 149-151 https://doi.org/10.1111/j.1751-0813.1987.tb09667.x
  6. Hooper PT. Cycad poisoning in Australia-etiology and pathology. In: Keeler RF, van Kampen KR, James LF (eds.). Effects of Poisonous Plants on Livestock. pp. 337-347, Academic Press, New York, 1978
  7. Hooper PT, Best SM, Campbell A. Axonal dystrophy in the spinal cords of cattle consuming the cycad palm, Cycas media. Aust Vet J 1974, 50, 146-149 https://doi.org/10.1111/j.1751-0813.1974.tb06879.x
  8. MacLachlan NJ, Cullen JM. Liver, biliary system and exocrine pancreas. In: Thomson RG, Carlton WW, McGavin MD (eds.). Thomson's Special Veterinary Pathology. 2nd ed. pp. 81-115, Mosby, St. Louis, 1995
  9. Osweiler GD. Plant-related toxicoses In: Toxicology. pp. 361-407, Lippincott Williams & Wilkins, Philadelphia, 1996
  10. Overall KL. Miscellaneous behavioral problems: emphasis on management. In: Clinical Behavioral Medicine for Small Animals. pp. 251-273, Mosby, St. louis, 1997
  11. Plunkett SJ. Emergency Procedures for the Small Animal Veterinarian. p. 492, Saunders, Philadelphia, 2001
  12. Senior DF, Sundlof SF, Buergelt CD, Hines SA, O'Neil-Foil CS, Meyer DJ. Cycad intoxication in the dog. J Am Anim Hosp Assoc 1985, 21, 103-109
  13. Scherk MA, Center SA. Toxic, metabolic infectious and neoplastic liver diseases. In: Ettinger SJ, Feldman EC (eds.). Textbook of Veterinary Internal Medicine. 6th ed. pp. 1464-1478, Saunders, Philadelphia, 2005
  14. Stehbens WE. Oxidative stress, toxic hepatitis, and antioxidants with particular emphasis on zinc. Exp Mol Pathol 2003, 75, 265-276 https://doi.org/10.1016/S0014-4800(03)00097-2
  15. Willard MD, Twedt DC. Gastrointestinal, pancreatic and hepatic disorders In: Willard MD, Tvedten H, Turnwald GH (eds.). Small Animal Clinical Diagnosis by Laboratory Methods. 3rd ed. pp. 172-207, Saunders, Philadelphia, 1999