Investigative and Clinical Urology

The Korean Urological Association (대한비뇨의학회)
권호 표지

Efficacy and Safety of a Herbal Formula that Mainly Consists of Cornus Officinalis for Erectile Dysfunction: A Double-blind, Placebo-controlled Study

산수유 복합 추출 분말이 발기 부전증 환자에 미치는 임상적 효과와 안전성

Kam, Sung-Chul;Choi, See-Min;Jeh, Sung-Uk;Lee, Seung-Hyun;Hwa, Jeong-Seok;Jung, Ky-Hyun;Kang, Chang-Wan;Hyun, Jae-Seog
감성철;최세민;제성욱;이승현;화정석;정기현;강창완;현재석

  • Published : 20070700
⟨ Previous Next ⟩

Abstract

The aim of this study was to evaluate the efficacy and safety of a herbal formula that mainly consists of Cornus officinalis for treating erectile dysfunction. Materials and Methods: Eighty patients suffering with erectile dysfunction were enrolled in this randomized, double-blinded, placebo-controlled study. The average duration of erectile dysfunction of the herbal formula group(n=40) vs. the placebo group(n=40) were 19.33±18.13 months vs. 19.33±25.62 months, respectively. The safety variables we examined were the history, physical examination, vital signs, EKG, clinical laboratory tests and hormonal tests. Efficacy assessments included the International Index of Erectile Function(IIEF), the sexual encounter profile(SEP) diary and Global Assessment Questions(GAQ). Results: No significant changes in the laboratory values, hormone tests and blood pressure were observed in both groups. In comparison with the placebo group(6.57±11.72), the herbal formula group experienced a significant improvement of the IIEF(11.13±11.83)(p＜0.05). When the herbal formula and placebo groups were divided by age and the IIEF score (age: 50 years and IIEF: 42) and then compared, the low IIEF group(IIEF≤42) and old age group(age≥50) of the herbal formula group significantly improved their IIEF score(p＜0.05). The herbal formula group significantly improved their GAQ score(p＜0.05). The herbal formula was well tolerated. The common adverse events were headache(2.5%) and nausea(5%). Conclusions: In conclusion, the herbal formula that mainly consists Cornus officinalis was not only effective at improving erectile function, but it was also safe for the treatment of erectile dysfunction.

Keywords

References

  1. Kinsey AC. Age and sexual outlet. In: Kinsey AC, Pomeroy WB, Martin CE, editors. Sexual behavior in the human male. 1st ed. Philadelphia: WB Saunders; 1948;218-62
  2. Johannes CB, Araujo AB, Feldman HA, Derby CA, Kleinman KP, McKinlay JB. Incidence of erectile dysfunction in men 40 to 69 years old: longitudinal results from the Massachusetts male aging study. J Urol 2000;163:460-3 https://doi.org/10.1016/S0022-5347(05)67900-1
  3. Derby CA, Araujo AB, Johannes CB, Feldman HA, McKinlay JB. Measurement of erectile dysfunction in population-based studies: the use of a single question self-assessment in the Massachusetts Male Aging Study. Int J Impot Res 2000;12: 197-204 https://doi.org/10.1038/sj.ijir.3900542
  4. Kim TH, Chung TG, Ahn TY. Relation between lower urinary tract symptoms and erectile dysfunction: epidemiologic study in Jeong-Eup, Korea. Korean J Androl 1998;16:87-91
  5. Ryu SB, Min KD, Park KS, Park YG, Rhee JG, Kweon SS. Epidemiologic study of the male erectile dysfunction with risk factors in rural area. Korean J Androl 2001;19:125-31
  6. Zheng BL, He K, Kim CH, Rogers L, Shao YU, Huang ZY, et al. Effect of a lipidic extract from lepidium meyenii on sexual behavior in mice and rats. Urology 2000;55:598-602 https://doi.org/10.1016/S0090-4295(99)00549-X
  7. Hadidi KA, Aburjai T, Battah AK. A comparative study of Ferula hermonis root extracts and sildenafil on copulatory behaviour male rats. Fitoterapia 2003;74:242-6 https://doi.org/10.1016/S0367-326X(03)00032-7
  8. Kim DW, Kim DH, Choi DW, Kim DH, Jung GW. Effects of Ginseng alkaloid on the tension of rabbit corpus cavernosum. Korean J Androl 2002;20:16-22
  9. Kim SW, Paick SC. Clinical efficacy of Korean red Ginseng on vasculogenic impotent patients. Korean J Androl 1999;17: 23-8
  10. Park HC, Park HJ, Park NC. The clinical trial of apomorphine hydrochloride SL (Uprima$^{\circledR}$) in patients with erectile dysfunction. Korean J Urol 2003;44:1038-44
  11. Meuleman E, Cuzin B, Opsomer RJ, Hartmann U, Bailey MJ, Maytom MC, et al. A dose-escalation study to assess the efficacy and safety of sildenafil citrate in men with erectile dysfunction. BJU Int 2001;87:75-81 https://doi.org/10.1046/j.1464-410x.2001.00998.x
  12. Goldstein I, Lue TF, Padma-Nathan H, Rosen RC, Steers WD, Wicker PA. Oral sildenafil in the treatment of erectile dysfunction. 1998. J Urol 2002;167:1197-203 https://doi.org/10.1016/S0022-5347(02)80386-X
  13. Tamaoki J, Nakata J, Kawatani K, Tagaya E, Nagai A. Ginsenoside-induced relaxation of human bronchial smooth muscle via release of nitric oxide. Br J Pharmacol 2000; 130:1859-64 https://doi.org/10.1038/sj.bjp.0703511
  14. Hong B, Ji YH, Hong JH, Nam KY, Ahn TY. A double-blind crossover study evaluating the efficacy of Korean red ginseng in patients with erectile dysfunction: a preliminary report. J Urol 2002;168:2070-3 https://doi.org/10.1016/S0022-5347(05)64298-X
  15. Park CS, Ryu SD, Hwang SY. Elevation of intracavernous pressure and NO-cGMP activity by a new herbal formula in penile tissues of aged and diabetic rats. J Ethnopharmacol 2004;94:85-92 https://doi.org/10.1016/j.jep.2004.04.028
  16. Moyad MA, Barada JH, Lue TF, Mulhall JP, Goldstein I, Fawzy A. Prevention and treatment of erectile dysfunction using lifestyle changes and dietary supplements: what works and what is worthless, part I. Urol Clin North Am 2004; 31:249-57 https://doi.org/10.1016/j.ucl.2004.01.006