Treatment of Partial Thickness Skin Defect with Cultured Allogenic Keratinocytes (Kaloderm®)

동종유래각질세포(Cultured Allogenic Keratinocytes, Kaloderm®)를 이용한 부분층 피부 결손의 치료

  • Seo, Sang Won (Department of Plastic and Reconstructive Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine,) ;
  • Chang, Choong Hyun (Department of Plastic and Reconstructive Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine,) ;
  • Cho, Min Su (Department of Plastic and Reconstructive Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine,) ;
  • Hong, Yoon Gi (Department of Plastic and Reconstructive Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine,) ;
  • Jeon, Sae Wha (Tego Science Inc.)
  • 서상원 (성균관대학교 의과대학 강북삼성병원 성형외과학교실) ;
  • 장충현 (성균관대학교 의과대학 강북삼성병원 성형외과학교실) ;
  • 조민수 (성균관대학교 의과대학 강북삼성병원 성형외과학교실) ;
  • 홍윤기 (성균관대학교 의과대학 강북삼성병원 성형외과학교실) ;
  • 전세화 (테고 사이언스(주))
  • Received : 2006.11.17
  • Accepted : 2007.03.21
  • Published : 2007.06.30

Abstract

Purpose: Grafting with autograft skin remains the most effective method for treating skin defects. When insufficient donor sites are present or patients are afraid of the operation, a skin graft is impossible. Cultured allogenic keratinocytes speed wound healing by providing cover and by producing growth factors and extracellular matrix protein. We report an application of cultured allogenic keratinocytes ($Kaloderm^{(R)}$, Tegoscience, Seoul, Korea) in the treatment of an acute partial thickness skin defect. Methods: From March 2005 to January 2006, 20 patients with a partial thickness skin defect were treated with cultured allogenic keratinocytes. The wound was covered with a sheet of cultured allogenic keratinocytes and ointment with $Bactigras^{(R)}$ gauze. The wound was inspected every two or three days. We regarded completion of epithelialization as wound healing. Results: The mean period between time of injury and time of $Kaloderm^{(R)}$ application was 7.5 days. The time taken from application of $Kaloderm^{(R)}$ to complete closure of the wounds was 7.2 days. Conclusion: In view of the favorable outcome, cultured allogenic keratinocytes are safe and effective biologic dressing materials for use in the treatment of open wounds.

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