Journal of Microbiology

The Microbiological Society of Korea (한국미생물학회)
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Analysis of Substitution Events in HIV-1 vif Gene of the Korean Clade

  • Park, Chan-Seung (School of Life Sciences, Chungbuk National University) ;
  • Kim, Mi-Sook (School of Life Sciences, Chungbuk National University) ;
  • Yi, Hyun-Ah (School of Life Sciences, Chungbuk National University) ;
  • Lee, Dong-Hun (School of Life Sciences, Chungbuk National University) ;
  • Lee, Keon-Myung (School of Electrical and Computer Engineering, Chungbuk National University) ;
  • Lee, Chan-Hee (School of Life Sciences, Chungbuk National University)
  • Published : 2007.02.22
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Abstract

Nucleotide and amino acid substitution pattern in vif gene of the Korean clade of HIV-1 isolated from Koreans were analyzed using consensus sequences. At nucleotide level, transition/transversion substitution ratio was 1.88, and nonsynonymous/synonymous substitution ratio was 2.67, suggesting a divergent evolution in the Korean clade. At amino acid level, there were 17 substitutions and $G{\rightarrow}E$ substitution at position 37 may be responsible for change in predicted secondary structure.

Keywords

References

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