Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
권호 표지
DOI QR코드

DOI QR Code

Effects of Natural Plants Supplementation on Adipocyte Size of the Epididymal Fat Pads in Rats

천연소재 흔합물의 보충급여가 부고환 지방세포 크기에 미치는 영향

  • Kim, Hyun-Sook (BK21 Nutraceutical, Kangwon National University) ;
  • Kim, Tae-Woo (Dept. of Animal Products Science, Kangwon National University) ;
  • Kim, Dae-Jung (Dept. of Plant Biotechnology, Kangwon National University) ;
  • Hwang, Ha-Jin (Dept. of Plant Biotechnology, Kangwon National University) ;
  • Lee, Hyun-Joo (Dept. of Plant Biotechnology, Kangwon National University) ;
  • Choe, Myeon (Dept. of Plant Biotechnology, Kangwon National University)
  • 김현숙 (강원대학교 BK21 뉴트라슈티컬사업단) ;
  • 김태우 (강원대학교 축산식품과학과) ;
  • 김대중 (강원대학교 식물생명공학과) ;
  • 황하진 (강원대학교 식물생명공학과) ;
  • 이현주 (강원대학교 식물생명공학과) ;
  • 최면 (강원대학교 식물생명공학과)
  • Published : 2007.04.30
Download PDF
⟨ Previous Next ⟩

Abstract

Obesity is increasingly recognized as a serious public health threat. Anti-obesity nutraceuticals that are safe and effective for the control and treatment of obesity are the subject of intense research throughout the world. The purpose of this study was to assess the effects of plants such as Akebia quinata, corn silk, Crataegus pinnatifida var. psilosa, Coix lachrymajobi var. mayuen, and Lentinus edodes on fat cell size and serum lipid profile of rats. Male Sprague-Dawley rats were weighed, randomly assigned and fed AIN-76A basal or high fat diet for 6 weeks. Serum triacylglycerol level of rats fed a normal diet was significantly decreased with natural plants supplementation. Adipocytes from the epididymal fat pads of rats fed a high fat diet were larger than those of rats fed a normal diet. Fat cell size significantly (p<0.05) decreased with natural plants supplementation. Therefore, we found that natural plants supplementation can be used for the treatment of obesity, possibly by decreasing the body fat.

본 연구에서는 천연소재 혼합물이 혈중 지질 함량 및 부고환 지방세포의 크기에 미치는 영향을 측정하였다. 그 결과 혈액 중 총 콜레스테롤과 LDL 콜레스테롤은 천연소재 섭취에 의한 유의적인 감소 효과가 나타나지 않았지만, 중성지방은 정상식이군에서 감소하였고 HDL 콜레스테롤은 정 상식이군에서 증가하였다. 부고환 지방조직은 고지방식이 섭취에 의해 지방세포 크기가 유의적으로 증가되었으나 천연소재 섭취로 인하여 유의적으로 감소하였다. 이는 천연소재섭취에 의해 체지방 축적이 억제되어 지방세포의 hypertrophy를 억제했기 때문으로 사료된다.

Keywords

References

  1. Grundy SM. 1998. Multifactorial causation of obesity: implications for prevention. Am J Clin Nutr 67: 563S-572S https://doi.org/10.1093/ajcn/67.3.563S
  2. Albu J, Allison D, Boozer CN, Heymsfield S, Kissileff H, Kretser A, Krumhar K, Leibei R, Nonas C, Pi-Sunyer X, Vanltallie T, Wedral E. 1997. Obesity solutions: report of a meeting. Nutr Res 55: 150-156
  3. Kim YJ, Kim BH, Lee SY, Kim MS, Park CS, Rhee MS, Lee KH, Kim DS. 2006. Screening of medicinal plants for development of functional food ingredients with anti-obesity. J Korean Soc Appl Biol Chem 49: 221-226
  4. Kim YS, Byun SH, Kim SC, Kum M, Cho EH. 2000. Effect on cure and prevention of an obesity. Kor J Herboloy 15: 37-43
  5. Jeon JR, Kim JY, Lee KM, Cho DH. 2005. Anti-obese effects of mixture contained pine needle, black tea and green tea extracts. J Korean Soc Appl Biol Chem 48: 375-381
  6. Kang KJ, Lim SJ, Jeong JG, Han HK, Choi SS, Kim MH, Kwon SY. 2003. Effects of wax guard on weight, triglyceride, leptin and fat cell size in rats fed on a high fat diet. Korean J Nutr 36: 446-451
  7. Kang SA, Jang KH, Hong KH, Choi WA, Jung KH, Lee IY. 2002. Effects of dietary ${\beta}$-glucan on adiposity and serum lipids levels in obese rats induced by high fat diet. J Korean Soc Food Sci Nutr 31: 1052-1057 https://doi.org/10.3746/jkfn.2002.31.6.1052
  8. Moon GA, Choi SM, Kim SH, Kim SS, Kang JY, Yoon Y. 2003. Human and animal study on the natural food for obesity and metabolic syndrome risk factors. J Korean Soc Food Sci Nutr 32: 1394-1400 https://doi.org/10.3746/jkfn.2003.32.8.1394
  9. Kim JB. 2001. New horizon in atherosclerosis research: Insights into fat cell differentiation and insulin sensitivity with ADD1/SREBP1 and PPAR ${\gamma}$. Korean J Lipidol 11: 79-83
  10. Sisk M, Azin MJ, Hausman DB, Jewell DE. 1999. Effect of conjugated linoleic acid on fat pad weights and cellularity in Sprague Dawley and Zucker rats. FASEB 3116: A536
  11. Flier JS. 1995. The adipocyte: storage depot or node on the energy information superhighway. Cell 80: 15-18 https://doi.org/10.1016/0092-8674(95)90445-X
  12. Friewald WT, Levy RI, Fedreicson DS. 1972. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without was of the preparative ultracentrafuge. Clin Chem 18: 499-506
  13. Chen HC, Farese RV Jr. 2002. Determination of adipocyte size by computer image analysis. J Lipid Res 43: 986-989
  14. Bjorntorp P. 1998. The associations between obesity, adipose tissue distribution and disease. Acta Med Scand 723: 121-134
  15. Bjorntorp P. 1990. 'Portal' adipose tissue as a generator of risk factors for cardiovascular disease and diabetes. Arterioscrosis 10: 493-496 https://doi.org/10.1161/01.ATV.10.4.493
  16. Kang KJ, Choi SS, Han HK, Kim KJ, Kwon SY. 2004. Effects of instant coffee on weight, plasma lipids, leptin, and fat cell size in rats fed on a high fat diet. Korean J Food Sci Technol 36: 478-483
  17. Hong HD, Kim YC, Keum IK, Kim SS, Kim KI, Han CK. 2005. Effect of Gastrodiae rhizoma fractions on serum lipid concentrations in rats fed with high fat diet. J Korean Soc Appl Biol Chem 48: 370-374
  18. Lee JS, Lee KH, Jeong JH. 1999. Effects of extract of Pueraria radix on lipid metabolism in rats fed high fat diet. J Korean Soc Food Sci Nutr 28: 218-224
  19. Shimoda H, Seki E, Aitani M. 2006. Inhibitory effect of green coffee bean extract on fat accumulation and body weight gain in mice. BMC Complement Altern Med 6: 9-17 https://doi.org/10.1186/1472-6882-6-9

Cited by

  1. Anti-obesity Effects of Extracts from Young Akebia quinata D. Leaves vol.43, pp.2, 2014, https://doi.org/10.3746/jkfn.2014.43.2.200
  2. Anti-Obesity Effects of Foeniculum fructus Water Extract vol.39, pp.11, 2010, https://doi.org/10.3746/jkfn.2010.39.11.1604
  3. Antiobese Effects of Diet Containing Medicinal Plant Water Extracts in High Fat Diet-Induced Obese Mice vol.38, pp.11, 2009, https://doi.org/10.3746/jkfn.2009.38.11.1522
  4. Peanut sprouts extract (Arachis hypogaeaL.) has anti-obesity effects by controlling the protein expressions of PPARγ and adiponectin of adipose tissue in rats fed high-fat diet vol.8, pp.2, 2014, https://doi.org/10.4162/nrp.2014.8.2.158
  5. Effect of Pumpkin, Corn Silk, Adzuki Bean, and Their Mixture on Weight Control and Antioxidant Activities in High Fat Diet-Induced Obesity Rats vol.45, pp.9, 2016, https://doi.org/10.3746/jkfn.2016.45.9.1239
  6. Anti-Obesity Effect of Fructus Pyri Pyrifoliae Extract Fermented by Lactic-Acid Bacteria on Rats vol.48, pp.3, 2018, https://doi.org/10.9729/am.2018.48.3.62
  7. Anti-Obesity Effects of Grateloupia elliptica , a Red Seaweed, in Mice with High-Fat Diet-Induced Obesity via Suppression of Adipogenic Factors in White Adipose Tissue and Increased Thermogenic Facto vol.12, pp.2, 2007, https://doi.org/10.3390/nu12020308
  8. Antiobesity Effects of Extract from Spergularia marina Griseb in Adipocytes and High-Fat Diet-Induced Obese Rats vol.12, pp.2, 2007, https://doi.org/10.3390/nu12020336